Joris A F van Loenhout1, Jeannine L A Hautvast2, Jan H Vercoulen3, Reinier P Akkermans4, Clementine J Wijkmans5, Koos van der Velden6, W John Paget7. 1. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands. Electronic address: joris.vanloenhout@radboudumc.nl. 2. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands. Electronic address: jeannine.hautvast@radboudumc.nl. 3. Department of Medical Psychology, Radboud University Medical Center, The Netherlands. Electronic address: jan.vercoulen@radboudumc.nl. 4. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands. Electronic address: reinier.akkermans@radboudumc.nl. 5. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands; Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, The Netherlands. Electronic address: c.wijkmans@ggdhvb.nl. 6. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands. Electronic address: koos.vandervelden@radboudumc.nl. 7. Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, The Netherlands; Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands. Electronic address: john.paget@radboudumc.nl.
Abstract
OBJECTIVES: During the largest Q-fever outbreak ever reported, a cohort study was established to assess the health status of Q-fever patients over a 24-month period and to identify factors associated with health status. METHODS: Laboratory-confirmed Q-fever patients participated at six time points after onset of illness. Scores on twelve subdomains from two health status instruments were calculated for each time point to determine progression and compare to reference groups. RESULTS: The study included 336 Q-fever patients. There is a significant linear improvement over time in nine of the twelve health status subdomains. For example, the proportion of patients with severe fatigue improved from 73.0% at three months to 60.0% at twelve months and 37.0% at twenty-four months, but this was still high compared to a healthy reference group (2.5%). For the three most severely affected subdomains -'Fatigue', 'General Quality of Life' and 'Role Physical'- the baseline characteristics significantly associated with a long-term reduced health status were being female, being a young adult and having pre-existing health problems. CONCLUSIONS: Despite a significant linear improvement over time in nine of the twelve health status subdomains, more than one out of three patients still suffered from a reduced health status at 24 months.
OBJECTIVES: During the largest Q-fever outbreak ever reported, a cohort study was established to assess the health status of Q-feverpatients over a 24-month period and to identify factors associated with health status. METHODS: Laboratory-confirmed Q-feverpatients participated at six time points after onset of illness. Scores on twelve subdomains from two health status instruments were calculated for each time point to determine progression and compare to reference groups. RESULTS: The study included 336 Q-feverpatients. There is a significant linear improvement over time in nine of the twelve health status subdomains. For example, the proportion of patients with severe fatigue improved from 73.0% at three months to 60.0% at twelve months and 37.0% at twenty-four months, but this was still high compared to a healthy reference group (2.5%). For the three most severely affected subdomains -'Fatigue', 'General Quality of Life' and 'Role Physical'- the baseline characteristics significantly associated with a long-term reduced health status were being female, being a young adult and having pre-existing health problems. CONCLUSIONS: Despite a significant linear improvement over time in nine of the twelve health status subdomains, more than one out of three patients still suffered from a reduced health status at 24 months.
Authors: James M Battisti; Lance A Watson; Myo T Naung; Adam M Drobish; Ekaterina Voronina; Michael F Minnick Journal: Innate Immun Date: 2016-11-24 Impact factor: 2.680
Authors: Gabriella Morroy; Stephan P Keijmel; Corine E Delsing; Gijs Bleijenberg; Miranda Langendam; Aura Timen; Chantal P Bleeker-Rovers Journal: PLoS One Date: 2016-05-25 Impact factor: 3.240
Authors: Ben Z Katz; Simon M Collin; Gabrielle Murphy; Rona Moss-Morris; Vegard Bruun Wyller; Knut-Arne Wensaas; Jeannine L A Hautvast; Chantal P Bleeker-Rovers; Ute Vollmer-Conna; Dedra Buchwald; Renée Taylor; Paul Little; Esther Crawley; Peter D White; Andrew Lloyd Journal: Fatigue Date: 2018-01-19
Authors: Daphne F M Reukers; Cornelia H M van Jaarsveld; Reinier P Akkermans; Stephan P Keijmel; Gabriella Morroy; Adriana S G van Dam; Peter C Wever; Cornelia C H Wielders; Koos van der Velden; Joris A F van Loenhout; Jeannine L A Hautvast Journal: PLoS One Date: 2022-02-02 Impact factor: 3.240