Wolfram Grimm1, Antonina Sosnovskaya2, Nina Timmesfeld3, Olaf Hildebrandt4, Ulrich Koehler4. 1. Department of Cardiology, University Hospital of Marburg and Gießen, Marburg, Germany. Electronic address: grimmw@med.uni-marburg.de. 2. Department of Cardiology, University Hospital of Marburg and Gießen, Marburg, Germany. 3. Institute for Medical Biometry and Epidemiology, Philipps-University Marburg, Marburg, Germany. 4. Sleep Disorder Unit of the Department of Pneumology, University Hospital of Marburg and Gießen, Marburg, Germany.
Abstract
BACKGROUND: Central sleep apnea (CSA) is common in patients with heart failure (HF). Earlier studies investigating the influence of CSA on mortality in HF patients, however, have yielded contradictory results. METHODS AND RESULTS: In a prospective study involving 267 patients with left ventricular (LV) ejection fractions ≤50%, we performed polysomnography and compared heart transplant-free survival rates between patients with no or mild CSA (apnea-hypopnea index [AHI] ≤15/h) and those with moderate CSA (AHI 15.1-30/h) or severe CSA (AHI >30/h). During 43 ± 18 months' mean follow-up, 67 patients (25%) died and 4 patients (1%) underwent heart transplantation. Multivariate Cox analysis identified age, male sex, chronic kidney disease, and decreased LV ejection fraction, but not moderate CSA or severe CSA, as predictors of transplant-free survival. CONCLUSIONS: In patients with stable HF, moderate CSA as well as severe CSA do not appear to predict transplant-free survival independently from confounding factors.
BACKGROUND:Central sleep apnea (CSA) is common in patients with heart failure (HF). Earlier studies investigating the influence of CSA on mortality in HF patients, however, have yielded contradictory results. METHODS AND RESULTS: In a prospective study involving 267 patients with left ventricular (LV) ejection fractions ≤50%, we performed polysomnography and compared heart transplant-free survival rates between patients with no or mild CSA (apnea-hypopnea index [AHI] ≤15/h) and those with moderate CSA (AHI 15.1-30/h) or severe CSA (AHI >30/h). During 43 ± 18 months' mean follow-up, 67 patients (25%) died and 4 patients (1%) underwent heart transplantation. Multivariate Cox analysis identified age, male sex, chronic kidney disease, and decreased LV ejection fraction, but not moderate CSA or severe CSA, as predictors of transplant-free survival. CONCLUSIONS: In patients with stable HF, moderate CSA as well as severe CSA do not appear to predict transplant-free survival independently from confounding factors.
Authors: Francesco Gentile; Chiara Borrelli; Paolo Sciarrone; Francesco Buoncristiani; Jens Spiesshoefer; Francesca Bramanti; Giovanni Iudice; Giuseppe Vergaro; Michele Emdin; Claudio Passino; Alberto Giannoni Journal: J Am Heart Assoc Date: 2022-02-22 Impact factor: 6.106
Authors: João Pedro Ferreira; Kévin Duarte; Holger Woehrle; Martin R Cowie; Karl Wegscheider; Christiane Angermann; Marie-Pia d'Ortho; Erland Erdmann; Patrick Levy; Anita K Simonds; Virend K Somers; Helmut Teschler; Patrick Rossignol; Wolfgang Koenig; Faiez Zannad Journal: ESC Heart Fail Date: 2020-01-17