Mehraneh D Jafari1, Steven D Wexner2, Joseph E Martz3, Elisabeth C McLemore4, David A Margolin5, Danny A Sherwinter6, Sang W Lee7, Anthony J Senagore8, Michael J Phelan1, Michael J Stamos9. 1. Department of Surgery, University of California, Irvine Medical Center, Orange, CA. 2. Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL. 3. Department of Surgery, Beth Israel Medical Center, New York, NY. 4. Department of Surgery, University of California San Diego Medical Center, La Jolla, CA. 5. Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, LA. 6. Department of Surgery, Maimonides Medical Center, Brooklyn, NY. 7. Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY. 8. Surgical Disciplines, Central Michigan University, College of Medicine, Saginaw, MI. 9. Department of Surgery, University of California, Irvine Medical Center, Orange, CA. Electronic address: mstamos@uci.edu.
Abstract
BACKGROUND: Our primary objective was to demonstrate the utility and feasibility of the intraoperative assessment of colon and rectal perfusion using fluorescence angiography (FA) during left-sided colectomy and anterior resection. Anastomotic leak (AL) after colorectal resection increases morbidity, mortality, and, in cancer cases, recurrence rates. Inadequate perfusion may contribute to AL. The PINPOINT Endoscopic Fluorescence Imaging System allows for intraoperative assessment of anastomotic perfusion. STUDY DESIGN: This is a prospective, multicenter, open-label, clinical trial that assessed the feasibility and utility of FA for intraoperative perfusion assessment during left-sided colectomy and anterior resection at 11 centers in the United States. RESULTS: A total of 147 patients were enrolled, of whom 139 were eligible for analysis. Diverticulitis (44%), rectal cancer (25%), and colon cancer (21%) were the most prevalent indications for surgery. The mean level of anastomosis was 10 ± 4 cm from the anal verge. Splenic-flexure mobilization was performed in 81% and high ligation of the inferior mesenteric artery in 61.9% of patients. There was a 99% success rate for FA, and FA changed surgical plans in 11 (8%) patients, with the majority of changes occurring at the time of transection of the proximal margin (7%). Overall morbidity rates were 17%. The anastomotic leak rate was 1.4% (n = 2). There were no anastomotic leaks in the 11 patients who had a change in surgical plan based on intraoperative perfusion assessment with FA. CONCLUSIONS: PINPOINT is a safe and feasible tool for intraoperative assessment of tissue perfusion during colorectal resection. There were no anastomotic leaks in patients in whom the anastomosis was revised based on inadequate perfusion with FA.
BACKGROUND: Our primary objective was to demonstrate the utility and feasibility of the intraoperative assessment of colon and rectal perfusion using fluorescence angiography (FA) during left-sided colectomy and anterior resection. Anastomotic leak (AL) after colorectal resection increases morbidity, mortality, and, in cancer cases, recurrence rates. Inadequate perfusion may contribute to AL. The PINPOINT Endoscopic Fluorescence Imaging System allows for intraoperative assessment of anastomotic perfusion. STUDY DESIGN: This is a prospective, multicenter, open-label, clinical trial that assessed the feasibility and utility of FA for intraoperative perfusion assessment during left-sided colectomy and anterior resection at 11 centers in the United States. RESULTS: A total of 147 patients were enrolled, of whom 139 were eligible for analysis. Diverticulitis (44%), rectal cancer (25%), and colon cancer (21%) were the most prevalent indications for surgery. The mean level of anastomosis was 10 ± 4 cm from the anal verge. Splenic-flexure mobilization was performed in 81% and high ligation of the inferior mesenteric artery in 61.9% of patients. There was a 99% success rate for FA, and FA changed surgical plans in 11 (8%) patients, with the majority of changes occurring at the time of transection of the proximal margin (7%). Overall morbidity rates were 17%. The anastomotic leak rate was 1.4% (n = 2). There were no anastomotic leaks in the 11 patients who had a change in surgical plan based on intraoperative perfusion assessment with FA. CONCLUSIONS: PINPOINT is a safe and feasible tool for intraoperative assessment of tissue perfusion during colorectal resection. There were no anastomotic leaks in patients in whom the anastomosis was revised based on inadequate perfusion with FA.
Authors: Deborah S Keller; Richard Boulton; Manuel Rodriguez-Justo; Richard Cohen; Manish Chand Journal: J Fluoresc Date: 2018-04-26 Impact factor: 2.217
Authors: Sami A Chadi; Abe Fingerhut; Mariana Berho; Steven R DeMeester; James W Fleshman; Neil H Hyman; David A Margolin; Joseph E Martz; Elisabeth C McLemore; Daniela Molena; Martin I Newman; Janice F Rafferty; Bashar Safar; Anthony J Senagore; Oded Zmora; Steven D Wexner Journal: J Gastrointest Surg Date: 2016-09-16 Impact factor: 3.452
Authors: Lea A Moukarzel; Maureen E Byrne; Stephanie Leiva; Michelle Wu; Qin C Zhou; Alexia Iasonos; Nadeem R Abu-Rustum; Yukio Sonoda; Ginger Gardner; Mario M Leitao; Vance A Broach; Dennis S Chi; Kara Long Roche; Oliver Zivanovic Journal: Gynecol Oncol Date: 2020-05-24 Impact factor: 5.482