Maria da Graça Cantarelli1, Patrícia Nardin2, Andréia Buffon3, Murilo Castilhos Eidt4, Luiz Antônio Godoy5, Brisa S Fernandes2, Carlos-Alberto Gonçalves6. 1. Post Graduate Program in Neuroscience, Federal University of Rio Grande do Sul,Porto Alegre, Brazil. 2. Laboratory of Calcium Binding Proteins in the Central Nervous System, Post Graduate Program in Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 3. Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 4. Study Center José de Barros Falcão, Porto Alegre, Brazil. 5. São José Psychiatric Clinic, Porto Alegre, Brazil. 6. Post Graduate Program in Neuroscience, Federal University of Rio Grande do Sul,Porto Alegre, Brazil; Laboratory of Calcium Binding Proteins in the Central Nervous System, Post Graduate Program in Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: casg@ufrgs.br.
Abstract
BACKGROUND: Many peripheral biomarkers, including low cholesterol and its fractions, have been examined to identify suicidal behavior. Herein, we assessed serum lipid profile and some proteins putatively associated with suicidal behavior in subjects with mood disorder (bipolar disorder or major depressive disorder) with a recent suicide attempt and with no lifetime history of suicide attempts. METHODS: Fifty subjects had presented an episode of attempted suicide during the last 15 days, and 36 subjects had no history of any suicide attempt. We measured total cholesterol, HDL, LDL and triglycerides as well as serum leptin, brain-derived neurotrophic factor (BDNF), S100B and C-reactive protein (CRP). RESULTS: Individuals that had attempted suicide presented decreased body mass index (BMI) and waist circumference. After adjusting for these confounders, we found that triglycerides were decreased in attempted suicide subjects. We found no differences among total cholesterol, LDL, and HDL or leptin, S100B, CRP and BDNF. LIMITATIONS: This is a cross-sectional study, and we cannot therefore assess whether a decrease in triglycerides caused a mood episode with suicidal ideation that led to a suicide attempt or if the presence of a mood episode originated a loss of appetite and consequent loss of weight, therefore decreasing triglyceride levels. CONCLUSIONS: These results do not support the hypothesis that lower levels of cholesterol are associated with suicidal behavior in a mood disorder sample. However, our data support the idea that adiposity is differentiated in these patients (reduced BMI, waist circumference and serum triglycerides), which could lead to an altered communication between the adipose tissue and brain.
BACKGROUND: Many peripheral biomarkers, including low cholesterol and its fractions, have been examined to identify suicidal behavior. Herein, we assessed serum lipid profile and some proteins putatively associated with suicidal behavior in subjects with mood disorder (bipolar disorder or major depressive disorder) with a recent suicide attempt and with no lifetime history of suicide attempts. METHODS: Fifty subjects had presented an episode of attempted suicide during the last 15 days, and 36 subjects had no history of any suicide attempt. We measured total cholesterol, HDL, LDL and triglycerides as well as serum leptin, brain-derived neurotrophic factor (BDNF), S100B and C-reactive protein (CRP). RESULTS: Individuals that had attempted suicide presented decreased body mass index (BMI) and waist circumference. After adjusting for these confounders, we found that triglycerides were decreased in attempted suicide subjects. We found no differences among total cholesterol, LDL, and HDL or leptin, S100B, CRP and BDNF. LIMITATIONS: This is a cross-sectional study, and we cannot therefore assess whether a decrease in triglycerides caused a mood episode with suicidal ideation that led to a suicide attempt or if the presence of a mood episode originated a loss of appetite and consequent loss of weight, therefore decreasing triglyceride levels. CONCLUSIONS: These results do not support the hypothesis that lower levels of cholesterol are associated with suicidal behavior in a mood disorder sample. However, our data support the idea that adiposity is differentiated in these patients (reduced BMI, waist circumference and serum triglycerides), which could lead to an altered communication between the adipose tissue and brain.
Authors: Leah M Hecht; Hsueh-Han Yeh; Jordan M Braciszewski; Lisa R Miller-Matero; Anjali Thakrar; Shivali Patel; Gregory E Simon; Frances L Lynch; Arne Beck; Ashli A Owen-Smith; Rebecca C Rossom; Beth E Waitzfelder; Christine Y Lu; Jennifer M Boggs; Brian K Ahmedani Journal: Psychiatr Serv Date: 2021-04-22 Impact factor: 4.157
Authors: A Messaoud; R Mensi; A Mrad; A Mhalla; I Azizi; B Amemou; I Trabelsi; M H Grissa; N Haj Salem; A Chadly; W Douki; M F Najjar; L Gaha Journal: Ann Gen Psychiatry Date: 2017-04-17 Impact factor: 3.455
Authors: Alessandro Miola; Veronica Dal Porto; Tal Tadmor; Giovanni Croatto; Paolo Scocco; Mirko Manchia; Andre F Carvalho; Michael Maes; Eduard Vieta; Fabio Sambataro; Marco Solmi Journal: Acta Psychiatr Scand Date: 2021-08-25 Impact factor: 7.734
Authors: Marcela Segoviano-Mendoza; Manuel Cárdenas-de la Cruz; José Salas-Pacheco; Fernando Vázquez-Alaniz; Osmel La Llave-León; Francisco Castellanos-Juárez; Jazmín Méndez-Hernández; Marcelo Barraza-Salas; Ernesto Miranda-Morales; Oscar Arias-Carrión; Edna Méndez-Hernández Journal: BMC Psychiatry Date: 2018-01-15 Impact factor: 3.630