Monica Aas1, Geir Pedersen2, Chantal Henry3, Thomas Bjella4, Frank Bellivier5, Marion Leboyer3, Jean-Pierre Kahn6, Renaud F Cohen6, Sebastien Gard7, Sofie R Aminoff8, Trine V Lagerberg4, Ole A Andreassen9, Ingrid Melle2, Bruno Etain10. 1. NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Electronic address: monica.aas@medisin.uio.no. 2. NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. 3. AP-HP, Hôpital H. Mondor - A. Chenevier, DHU Pepsy, Pôle de Psychiatry, Créteil 94000, France; Université Paris Est, Faculté de médecine, Créteil 94000, France; Inserm, U955, Créteil 94000, France; Fondation Fondamental, Créteil, France; ENBREC, European Network of Bipolar Research Expert Centres (ENBREC), Paris, France. 4. NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. 5. Inserm, U955, Créteil 94000, France; Fondation Fondamental, Créteil, France; AP-HP, GH Saint-Louis - Lariboisière - Fernand Widal, Pôle Neurosciences, Paris 75010, France; Université Paris 7, Denis Diderot, Paris, France; ENBREC, European Network of Bipolar Research Expert Centres (ENBREC), Paris, France. 6. Fondation Fondamental, Créteil, France; Service de Psychiatrie et Psychologie Clinique, Université de Lorraine et CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy 54500, France. 7. Fondation Fondamental, Créteil, France; Hôpital Charles Perrens, Centre Expert Trouble Bipolaire, Service de psychiatrie adulte, Pôle 3-4-7, Bordeaux 33000, France. 8. NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; Department of Specialized Inpatient Treatment, Division of Mental Health Services, Akershus University Hospital, 1478 Lørenskog, Norway. 9. NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; ENBREC, European Network of Bipolar Research Expert Centres (ENBREC), Paris, France. 10. AP-HP, Hôpital H. Mondor - A. Chenevier, DHU Pepsy, Pôle de Psychiatry, Créteil 94000, France; Inserm, U955, Créteil 94000, France; Fondation Fondamental, Créteil, France; ENBREC, European Network of Bipolar Research Expert Centres (ENBREC), Paris, France.
Abstract
INTRODUCTION: The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. METHODS: A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. RESULTS: Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. CONCLUSION: Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.
INTRODUCTION: The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. METHODS: A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. RESULTS: Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. CONCLUSION: Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.
Keywords:
ALS original 54 item version (ALS-54); ALS short 18 item version (ALS-18); Bipolar disorders; First-degree relatives; Healthy controls; Psychometric properties
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