Cumhur Tas1, Merve Cebi2, Oguz Tan2, Gokben Hızlı-Sayar2, Nevzat Tarhan3, Elliot C Brown4. 1. Department of Psychology, Uskudar University, İstanbul, Turkey; Division of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, Ruhr University, Bochum, NRW, Germany. Electronic address: cumhur.tas@uskudar.edu.tr. 2. Department of Psychology, Uskudar University, İstanbul, Turkey. 3. Division of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, Ruhr University, Bochum, NRW, Germany. 4. Division of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, Ruhr University, Bochum, NRW, Germany; Maryland Psychiatric Research Centre, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract
INTRODUCTION: Understanding the biological underpinnings of unipolar (UD) and bipolar depression (BD) is vital for avoiding inappropriate treatment through the misdiagnosis of bipolar patients in their first depressive episode. One plausible way to distinguish between UD and BD is to compare EEG brain dynamics to identify potential neurophysiological biomarkers. Here we aimed to test group differences in EEG power, cordance and coherence values between UD and BD. METHODS: Twenty-five bipolar and 56 unipolar depression patients were recruited. Sociodemographic and clinical variables were collected in addition to resting state EEG. Data was analyzed with multivariate and repeated analyses of variance where parametric assumptions were met. RESULTS: Accordingly, we did not find any differences in the EEG absolute power and frontal asymmetry indexes between UD and BD. Regarding cordance, significant group differences were observed in the right theta cordance values (p=0.031). Regarding coherence, BD patients (as compared to UD) exhibited greater central-temporal theta (p=0.003), and parietal-temporal alpha (p=0.007) and theta (p=0.001) coherence. Lastly, less alpha coherence in BD was present at right frontal-central (p=0.007) and central inter-hemispheric (p=0.019) regions. CONCLUSIONS: Our results demonstrate that EEG cordance and coherence values have potential to discriminate between UD and BD. The loss of temporal synchronization in the frontal interhemispheric and right sided frontolimbic neuronal networks may be a unique feature that distinguishes between BD and UD.
INTRODUCTION: Understanding the biological underpinnings of unipolar (UD) and bipolar depression (BD) is vital for avoiding inappropriate treatment through the misdiagnosis of bipolarpatients in their first depressive episode. One plausible way to distinguish between UD and BD is to compare EEG brain dynamics to identify potential neurophysiological biomarkers. Here we aimed to test group differences in EEG power, cordance and coherence values between UD and BD. METHODS: Twenty-five bipolar and 56 unipolar depressionpatients were recruited. Sociodemographic and clinical variables were collected in addition to resting state EEG. Data was analyzed with multivariate and repeated analyses of variance where parametric assumptions were met. RESULTS: Accordingly, we did not find any differences in the EEG absolute power and frontal asymmetry indexes between UD and BD. Regarding cordance, significant group differences were observed in the right theta cordance values (p=0.031). Regarding coherence, BD patients (as compared to UD) exhibited greater central-temporal theta (p=0.003), and parietal-temporal alpha (p=0.007) and theta (p=0.001) coherence. Lastly, less alpha coherence in BD was present at right frontal-central (p=0.007) and central inter-hemispheric (p=0.019) regions. CONCLUSIONS: Our results demonstrate that EEG cordance and coherence values have potential to discriminate between UD and BD. The loss of temporal synchronization in the frontal interhemispheric and right sided frontolimbic neuronal networks may be a unique feature that distinguishes between BD and UD.
Authors: Sungkean Kim; Ji Hyun Baek; Se-Hoon Shim; Young Joon Kwon; Hwa Young Lee; Jae Hyun Yoo; Ji Sun Kim Journal: Sci Rep Date: 2020-07-30 Impact factor: 4.379