Scott Travis1, Nicholas J Coupland2, Peter H Silversone2, Yushan Huang3, Esther Fujiwara2, Rawle Carter3, Peter Seres3, Nikolai V Malykhin4. 1. Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada. 2. Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada. 3. Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada. 4. Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada. Electronic address: nikolai@ualberta.ca.
Abstract
BACKGROUND: Magnetic resonance imaging (MRI) has shown lower hippocampal volume in major depressive disorder (MDD). Patients with MDD have consistently demonstrated worse performance than healthy controls a number of memory tests. Memory functions within the hippocampus in healthy younger subjects appear to be linked to cornu ammonis (CA1-3) and dentate gyrus (DG) subfields. Therefore, the main goal of the present study was to investigate whether memory deficits in MDD patients are related to reduction in hippocampal subfields volumes, particularly DG and CA 1-3. METHODS: 15 MDD patients meeting DSM-IV criteria for MDD with moderate or severe episodes were recruited, together with 15 healthy controls. We used T2-weighted 2D Fast Spin Echo (FSE) and T1-weighted 3D MPRAGE sequences at 4.7 T to compare hippocampal subfield volumes at 0.09 μl voxel volume. Participants were administered the Wechsler Memory Scale. RESULTS: MDD patients underperformed in several episodic visual memory tasks, as well as in visual working memory, compared to healthy controls. Global hippocampal volumes were similar between groups; however, MDD patients showed significantly reduced DG volumes within the hippocampal body. Duration of depression correlated with MDD patients׳ total volumes in the hippocampal body and CA1-3 and DG subfields within it. LIMITATIONS: Our study sample was relatively small and the majority of patients were on antidepressant treatment. CONCLUSIONS: Our findings suggest that DG volumes in particular may be worthy of further study to further elucidate their precise role in MDD, both by itself as well as in relation to memory.
BACKGROUND: Magnetic resonance imaging (MRI) has shown lower hippocampal volume in major depressive disorder (MDD). Patients with MDD have consistently demonstrated worse performance than healthy controls a number of memory tests. Memory functions within the hippocampus in healthy younger subjects appear to be linked to cornu ammonis (CA1-3) and dentate gyrus (DG) subfields. Therefore, the main goal of the present study was to investigate whether memory deficits in MDDpatients are related to reduction in hippocampal subfields volumes, particularly DG and CA 1-3. METHODS: 15 MDDpatients meeting DSM-IV criteria for MDD with moderate or severe episodes were recruited, together with 15 healthy controls. We used T2-weighted 2D Fast Spin Echo (FSE) and T1-weighted 3D MPRAGE sequences at 4.7 T to compare hippocampal subfield volumes at 0.09 μl voxel volume. Participants were administered the Wechsler Memory Scale. RESULTS:MDDpatients underperformed in several episodic visual memory tasks, as well as in visual working memory, compared to healthy controls. Global hippocampal volumes were similar between groups; however, MDDpatients showed significantly reduced DG volumes within the hippocampal body. Duration of depression correlated with MDDpatients׳ total volumes in the hippocampal body and CA1-3 and DG subfields within it. LIMITATIONS: Our study sample was relatively small and the majority of patients were on antidepressant treatment. CONCLUSIONS: Our findings suggest that DG volumes in particular may be worthy of further study to further elucidate their precise role in MDD, both by itself as well as in relation to memory.
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