Literature DB >> 25451045

Evolution of Staphylococcus aureus under vancomycin selective pressure: the role of the small-colony variant phenotype.

Justin R Lenhard1, Christof von Eiff2, Irene S Hong3, Patricia N Holden1, Michael D Bear1, Amy Suen1, Zackery P Bulman1, Brian T Tsuji4.   

Abstract

Staphylococcus aureus small-colony variants (SCVs) often persist despite antibiotic therapy. Against a 10(8)-CFU/ml methicillin-resistant S. aureus (MRSA) (strain COL) population of which 0%, 1%, 10%, 50%, or 100% was an isogenic hemB knockout (Ia48) subpopulation displaying the SCV phenotype, vancomycin achieved maximal reductions of 4.99, 5.39, 4.50, 3.28, and 1.66 log10 CFU/ml over 48 h. Vancomycin at ≥16 mg/liter shifted a population from 50% SCV cells at 0 h to 100% SCV cells at 48 h, which was well characterized by a Hill-type model (R2>0.90).
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25451045      PMCID： PMC4335873          DOI： 10.1128/AAC.04508-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.

Authors:  Longzhu Cui; Hui-min Neoh; Akira Iwamoto; Keiichi Hiramatsu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-29       Impact factor: 11.205

2.  Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus.

Authors:  R C Massey; A Buckling; S J Peacock
Journal:  Curr Biol       Date:  2001-11-13       Impact factor: 10.834

Review 3.  The small colony variant (SCV) concept -- the role of staphylococcal SCVs in persistent infections.

Authors:  Christof von Eiff; Georg Peters; Karsten Becker
Journal:  Injury       Date:  2006-05       Impact factor: 2.586

4.  Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.

Authors:  Hoang Anh Nguyen; Olivier Denis; Anne Vergison; Anne Theunis; Paul M Tulkens; Marc J Struelens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

5.  Reduced glycopeptide and lipopeptide susceptibility in Staphylococcus aureus and the "seesaw effect": Taking advantage of the back door left open?

Authors:  Jessica K Ortwine; Brian J Werth; George Sakoulas; Michael J Rybak
Journal:  Drug Resist Updat       Date:  2013-10-25       Impact factor: 18.500

6.  Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.

Authors:  Michael M Mwangi; Shang Wei Wu; Yanjiao Zhou; Krzysztof Sieradzki; Herminia de Lencastre; Paul Richardson; David Bruce; Edward Rubin; Eugene Myers; Eric D Siggia; Alexander Tomasz
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-21       Impact factor: 11.205

7.  Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity.

Authors:  Thomas P Lodise; Ben Lomaestro; Jeffrey Graves; G L Drusano
Journal:  Antimicrob Agents Chemother       Date:  2008-01-28       Impact factor: 5.191

8.  Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.

Authors:  L G Garcia; S Lemaire; B C Kahl; K Becker; R A Proctor; O Denis; P M Tulkens; F Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2012-05-07       Impact factor: 5.191

9.  Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.

Authors:  Linda M Weigel; Don B Clewell; Steven R Gill; Nancye C Clark; Linda K McDougal; Susan E Flannagan; James F Kolonay; Jyoti Shetty; George E Killgore; Fred C Tenover
Journal:  Science       Date:  2003-11-28       Impact factor: 47.728

10.  Daptomycin pharmacodynamics against Staphylococcus aureus hemB mutants displaying the small colony variant phenotype.

Authors:  Damir Begic; Christof von Eiff; Brian T Tsuji
Journal:  J Antimicrob Chemother       Date:  2009-03-19       Impact factor: 5.790
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  8 in total

1.  High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii.

Authors:  Justin R Lenhard; Jürgen B Bulitta; Terry D Connell; Natalie King-Lyons; Cornelia B Landersdorfer; Soon-Ee Cheah; Visanu Thamlikitkul; Beom Soo Shin; Gauri Rao; Patricia N Holden; Thomas J Walsh; Alan Forrest; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  J Antimicrob Chemother       Date:  2016-09-15       Impact factor: 5.790

2.  Pharmacodynamics of colistin and fosfomycin: a 'treasure trove' combination combats KPC-producing Klebsiella pneumoniae.

Authors:  Miao Zhao; Zackery P Bulman; Justin R Lenhard; Michael J Satlin; Barry N Kreiswirth; Thomas J Walsh; Amanda Marrocco; Phillip J Bergen; Roger L Nation; Jian Li; Jing Zhang; Brian T Tsuji
Journal:  J Antimicrob Chemother       Date:  2017-07-01       Impact factor: 5.790

Review 3.  Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections.

Authors:  Barbara C Kahl; Karsten Becker; Bettina Löffler
Journal:  Clin Microbiol Rev       Date:  2016-04       Impact factor: 26.132

4.  Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure.

Authors:  Justin R Lenhard; Tanya Brown; Michael J Rybak; Calvin J Meaney; Nicholas B Norgard; Zackery P Bulman; Daniel A Brazeau; Steven R Gill; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2015-12-28       Impact factor: 5.191

5.  Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii.

Authors:  Justin R Lenhard; Jonathan S Gall; Jurgen B Bulitta; Visanu Thamlikitkul; Cornelia B Landersdorfer; Alan Forrest; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  Int J Antimicrob Agents       Date:  2016-09-20       Impact factor: 5.283

6.  Bacterial biofilm formation is variably inhibited by different formulations of antibiotic-loaded bone cement in vitro.

Authors:  Giovanni Balato; Emanuela Roscetto; Adriana Vollaro; Olimpio Galasso; Giorgio Gasparini; Tiziana Ascione; Maria Rosaria Catania; Massimo Mariconda
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2018-10-28       Impact factor: 4.342

7.  Characteristics of Staphylococcus aureus small colony variants isolated from wound specimen of a tertiary care hospital in China.

Authors:  Changhang Min; Haichen Wang; Fengjun Xia; Mengli Tang; Jun Li; Yongmei Hu; Qingya Dou; Mingxiang Zou
Journal:  J Clin Lab Anal       Date:  2021-11-27       Impact factor: 2.352

Review 8.  Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection.

Authors:  Benjamin E Johns; Kevin J Purdy; Nicholas P Tucker; Sarah E Maddocks
Journal:  Microbiol Insights       Date:  2015-09-22
  8 in total

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