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Literature DB >> 25451008

Structural basis of cell apoptosis and necrosis in TNFR signaling.

Jing Huang¹, Shaoning Yu, Chaoneng Ji, Jixi Li.

Abstract

The tumor necrosis factor receptors (TNFRs) play essential roles in innate and adaptive immunity. Depending on conditions, TNFR induces multiple cell fates including cell survival, cell apoptosis, and cell programmed necrosis. Here, we review recent progress in structural studies of the TNFR signaling pathway. The structural basis for the high order signal complexes, including the DISC, ripoptosome, necrosome, and RIP3/MLKL complex, may provide novel insights for understanding the biophysical principles of cell signaling cascades.

Entities: Disease Gene

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Year: 2015 PMID： 25451008 DOI： 10.1007/s10495-014-1061-5

Source DB: PubMed Journal: Apoptosis ISSN： 1360-8185 Impact factor: 4.677

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Cited

11 in total

1. The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.

Authors: Jonathan Vial; Amélie Royet; Philippe Cassier; Antonin Tortereau; Sarah Dinvaut; Denis Maillet; Lise Gratadou-Hupon; Marion Creveaux; Alexa Sadier; Garance Tondeur; Sophie Léon; Lauriane Depaepe; Sophie Pantalacci; Arnaud de la Fouchardière; Olivier Micheau; Stéphane Dalle; Vincent Laudet; Patrick Mehlen; Marie Castets
Journal: Cell Death Differ Date: 2018-05-31 Impact factor: 15.828

Review 2. The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy.

Authors: Hiroyuki Takahashi; Gumpei Yoshimatsu; Denise Louise Faustman
Journal: Cells Date: 2022-06-17 Impact factor: 7.666

Structural basis of cell apoptosis and necrosis in TNFR signaling.

1. The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.

Review 2. The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy.

Review 3. Autophagy dysfunction in autoinflammatory diseases.

Review 4. The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products.

5. TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3.

6. Mechanism of Apoptosis Induction by Mycoplasmal Nuclease MGA_0676 in Chicken Embryo Fibroblasts.

Review 7. Unleashing endogenous TNF-alpha as a cancer immunotherapeutic.

Review 8. The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD.

9. E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis.

Review 10. TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors.