Kathleen E O'Neill1, Suneeta Senapati2, Anuja Dokras1. 1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. 2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address: Suneeta.Senapati@uphs.upenn.edu.
Abstract
OBJECTIVE: To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. DESIGN: Retrospective cohort study. SETTING: Academic center. PATIENT(S): Forty women with PCOS and 74 hyper-responders without PCOS. INTERVENTION(S): GnRHa trigger. MAIN OUTCOME MEASURE(S): Number of oocytes. RESULT(S): Serum E2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS). CONCLUSION(S): The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS.
OBJECTIVE: To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. DESIGN: Retrospective cohort study. SETTING: Academic center. PATIENT(S): Forty women with PCOS and 74 hyper-responders without PCOS. INTERVENTION(S): GnRHa trigger. MAIN OUTCOME MEASURE(S): Number of oocytes. RESULT(S): Serum E2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS). CONCLUSION(S): The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS.
Authors: B C Fauser; D de Jong; F Olivennes; H Wramsby; C Tay; J Itskovitz-Eldor; H G van Hooren Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958
Authors: Senthil Kumar Aiyappan; Bulabai Karpagam; V Vadanika; Prem Kumar Chidambaram; S Vinayagam; K C Saravanan Journal: J Clin Diagn Res Date: 2016-01-01