Leonardo Mastropasqua1, Lisa Toto2, Peter A Mattei1, Luca Vecchiarino1, Alessandra Mastropasqua1, Riccardo Navarra1, Marta Di Nicola1, Mario Nubile1. 1. From the Ophthalmology Clinic (L. Mastropasqua, Toto, Mattei, Vecchiarino, Nubile), Department of Medicine and Science of Ageing, Department of Neuroscience and Imaging (Navarra), Institute of Advanced Biomedical Technologies, and Department of Experimental and Clinical Sciences (Di Nicola), Laboratory of Biostatistics, University G. D'Annunzio Chieti-Pescara, Chieti, and the Ophthalmic Clinic (A. Mastropasqua), Campus Biomedico, University of Rome, Rome, Italy. 2. From the Ophthalmology Clinic (L. Mastropasqua, Toto, Mattei, Vecchiarino, Nubile), Department of Medicine and Science of Ageing, Department of Neuroscience and Imaging (Navarra), Institute of Advanced Biomedical Technologies, and Department of Experimental and Clinical Sciences (Di Nicola), Laboratory of Biostatistics, University G. D'Annunzio Chieti-Pescara, Chieti, and the Ophthalmic Clinic (A. Mastropasqua), Campus Biomedico, University of Rome, Rome, Italy. Electronic address: totolisa@hotmail.com.
Abstract
PURPOSE: To compare the features of capsulotomy obtained during femtosecond laser-assisted cataract surgery with those of continuous curvilinear capsulorhexis (CCC) obtained using a standard manual technique. SETTING: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy. DESIGN: Prospective randomized clinical study. METHODS:Candidates for cataract extraction were randomized into 1 of 3 groups as follows: Lensx femtosecond laser-assisted cataract surgery capsulotomy (laser group 1), Lensar femtosecond laser-assisted cataract surgery capsulotomy (laser group 2), and manual CCC (manual group). RESULTS: Each group comprised 30 eyes (30 patients). The capsulotomies in laser group 1 and laser group 2 showed significantly better circularity than the manual CCCs at 7 days (P<.001). There was a significant correlation between the intended versus achieved capsulotomy size in the 2 laser groups. Both laser groups had better intraocular lens (IOL) centration than the manual group at all timepoints (P<.001). Between-group differences in uncorrected and corrected distance visual acuities were not statistically significant. The residual spherical equivalent and mean absolute error were statistically significantly smaller in the 2 laser groups than in the manual group (P=.038) and increased significantly over time in all the groups (P<.001). CONCLUSIONS:Femtosecond laser capsulotomies showed better circularity with more predictable size than manual CCCs. In addition, IOL centration was better immediately after surgery and over time with better refractive results in the 2 laser groups.
RCT Entities:
PURPOSE: To compare the features of capsulotomy obtained during femtosecond laser-assisted cataract surgery with those of continuous curvilinear capsulorhexis (CCC) obtained using a standard manual technique. SETTING: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy. DESIGN: Prospective randomized clinical study. METHODS: Candidates for cataract extraction were randomized into 1 of 3 groups as follows: Lensx femtosecond laser-assisted cataract surgery capsulotomy (laser group 1), Lensar femtosecond laser-assisted cataract surgery capsulotomy (laser group 2), and manual CCC (manual group). RESULTS: Each group comprised 30 eyes (30 patients). The capsulotomies in laser group 1 and laser group 2 showed significantly better circularity than the manual CCCs at 7 days (P<.001). There was a significant correlation between the intended versus achieved capsulotomy size in the 2 laser groups. Both laser groups had better intraocular lens (IOL) centration than the manual group at all timepoints (P<.001). Between-group differences in uncorrected and corrected distance visual acuities were not statistically significant. The residual spherical equivalent and mean absolute error were statistically significantly smaller in the 2 laser groups than in the manual group (P=.038) and increased significantly over time in all the groups (P<.001). CONCLUSIONS: Femtosecond laser capsulotomies showed better circularity with more predictable size than manual CCCs. In addition, IOL centration was better immediately after surgery and over time with better refractive results in the 2 laser groups.