Literature DB >> 2545017

Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein.

J Abel1, N de Ruiter.   

Abstract

The effect of metallothionein (MT) on hydroxyl-radical-induced DNA damage was investigated in an in-vitro study. The degradation of DNA as demonstrated by agarose gel electrophoresis was inhibited by MT in a concentration-dependent manner. The degradation of DNA was almost completely inhibited by a concentration of 13 microM MT, whereas a concentration of 10 mM glutathione was needed to achieve the same protective effect.

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Year:  1989        PMID： 2545017     DOI： 10.1016/0378-4274(89)90075-1

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  34 in total

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Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

Review 2.  Brain injury and growth inhibitory factor (GIF)--a minireview.

Authors:  I Hozumi; T Inuzuka; S Tsuji
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Review 3.  Role of cellular antioxidants in metal-induced damage.

Authors:  M Sugiyama
Journal:  Cell Biol Toxicol       Date:  1994-02       Impact factor: 6.691

4.  Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements.

Authors:  T Dalton; R D Palmiter; G K Andrews
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

5.  Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease.

Authors:  T P Mulder; H W Verspaget; A R Janssens; P A de Bruin; A S Peña; C B Lamers
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Review 6.  Zinc and the modulation of redox homeostasis.

Authors:  Patricia I Oteiza
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7.  Antiapoptotic effect and inhibition of ischemia/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice.

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8.  New directions for studying the role of free radicals in aging.

Authors:  M A Pahlavani; H Van Remmen
Journal:  Age (Omaha)       Date:  1997-07

9.  Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients.

Authors:  Julie A Phillippi; Ekaterina A Klyachko; John P Kenny; Michael A Eskay; Robert C Gorman; Thomas G Gleason
Journal:  Circulation       Date:  2009-04-27       Impact factor: 29.690

10.  The Balance between Life and Death of Cells: Roles of Metallothioneins.

Authors:  Allan Evald Nielsen; Adam Bohr; Milena Penkowa
Journal:  Biomark Insights       Date:  2007-02-07
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