Literature DB >> 25449425

A review of biotransformation and pharmacology of ginsenoside compound K.

Xi-Ding Yang1, Yong-Yu Yang2, Dong-Sheng Ouyang3, Guo-Ping Yang4.   

Abstract

As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic, anti-inflammation, antiallergic, anti-diabetic, anti-angiogenesis, anti-aging, neuroprotective and hepatoprotective effects. The present review shall summarize recent studies on various biotransformation and pharmacological activities of CK.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biotransformation; Ginseng; Ginsenoside compound K; Pharmacological activities

Mesh：

Substances：

Year:  2014        PMID： 25449425     DOI： 10.1016/j.fitote.2014.11.019

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  63 in total

1.  Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model.

Authors:  Wu Song; Yan Guo; Shuang Jiang; Lin Wei; Zhi Liu; Xiaoyan Wang; Ying Su
Journal:  Neurochem Res       Date:  2018-05-22       Impact factor: 3.996

2.  Bioconversion, health benefits, and application of ginseng and red ginseng in dairy products.

Authors:  Jieun Jung; Na-Kyoung Lee; Hyun-Dong Paik
Journal:  Food Sci Biotechnol       Date:  2017-08-17       Impact factor: 2.391

3.  Ginsenoside Rg1 prevents starvation-induced muscle protein degradation via regulation of AKT/mTOR/FoxO signaling in C2C12 myotubes.

Authors:  Fengyu Li; Xiaoxue Li; Xuewei Peng; Lili Sun; Shengnan Jia; Ping Wang; Shuang Ma; Hongyan Zhao; Qingmiao Yu; Hongliang Huo
Journal:  Exp Ther Med       Date:  2017-06-15       Impact factor: 2.447

Review 4.  Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives.

Authors:  Wei-Na Li; Dai-Di Fan
Journal:  Appl Microbiol Biotechnol       Date:  2020-03-03       Impact factor: 4.813

5.  The Effects of a Korean Ginseng, GINST15, on Perceptual Effort, Psychomotor Performance, and Physical Performance in Men and Women.

Authors:  Lydia K Caldwell; William H DuPont; Matthew K Beeler; Emily M Post; Emily C Barnhart; Vincent H Hardesty; John P Anders; Emily C Borden; Jeff S Volek; William J Kraemer
Journal:  J Sports Sci Med       Date:  2018-03-01       Impact factor: 2.988

6.  Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Authors:  Jin-Yi Wan; Chong-Zhi Wang; Zhi Liu; Qi-Hui Zhang; Mark W Musch; Marc Bissonnette; Eugene B Chang; Ping Li; Lian-Wen Qi; Chun-Su Yuan
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2016-02-06       Impact factor: 3.205

Review 7.  Pharmacological properties of ginsenosides in inflammation-derived cancers.

Authors:  Do Luong Huynh; Nguyen Hoai Nguyen; Cuong Thach Nguyen
Journal:  Mol Cell Biochem       Date:  2021-04-26       Impact factor: 3.396

8.  Heterologous production of a ginsenoside saponin (compound K) and its precursors in transgenic tobacco impairs the vegetative and reproductive growth.

Authors:  Yu Shin Gwak; Jung Yeon Han; Prakash Babu Adhikari; Chang Ho Ahn; Yong Eui Choi
Journal:  Planta       Date:  2017-02-27       Impact factor: 4.116

9.  Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.

Authors:  Jingjing Zhang; Xiaoxuan Ma; Daidi Fan
Journal:  Foods       Date:  2021-05-26

Review 10.  Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook.

Authors:  Naila Qayyum; Muhammad Haseeb; Moon Suk Kim; Sangdun Choi
Journal:  Int J Mol Sci       Date:  2021-03-09       Impact factor: 5.923
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