PURPOSE: The aim of this retrospective study was to compare the competence of oocytes obtained from preovulatory and antral follicles. METHODS: Mature oocytes from preovulatory follicles were retrieved from women selected for standard IVF treatment (Group A). Mature oocytes from antral follicles were recovered from women undergoing hCG-primed in vitro maturation (IVM) treatment (Group B). Patients groups were matched for age, BMI, FSH, AMH and antral follicle count (AFC) values. In vivo matured oocytes from both groups were microinjected and resulting embryos were culture and selected on day 3 for embryo transfer. RESULTS: Oocyte pick-ups (OPU) were 315 and 204 in Groups A and B, respectively. Fertilization rates were comparable (72.8 and 75.9 %, respectively; P = 0.137). In Group A, in which the average number of embryos transferred was higher, clinical pregnancy rates per OPU (37.5 %) and embryo transfer (38.4 %) were superior in comparison to Group B (27.0 %, P = 0.013; 29.4 %, P = 0.041; respectively). On the other hand, implantation rates (Group A, 23.7 %; Group B, 20.8 %) and proportions of babies born per transferred embryo (Group A, 19.5 %; Group B, 16.9 %) were similar (P = 0.528 and 0.332, respectively). CONCLUSIONS: Overall, this suggests that oocyte competence is already achieved at the antral stage of follicle development.
PURPOSE: The aim of this retrospective study was to compare the competence of oocytes obtained from preovulatory and antral follicles. METHODS: Mature oocytes from preovulatory follicles were retrieved from women selected for standard IVF treatment (Group A). Mature oocytes from antral follicles were recovered from women undergoing hCG-primed in vitro maturation (IVM) treatment (Group B). Patients groups were matched for age, BMI, FSH, AMH and antral follicle count (AFC) values. In vivo matured oocytes from both groups were microinjected and resulting embryos were culture and selected on day 3 for embryo transfer. RESULTS: Oocyte pick-ups (OPU) were 315 and 204 in Groups A and B, respectively. Fertilization rates were comparable (72.8 and 75.9 %, respectively; P = 0.137). In Group A, in which the average number of embryos transferred was higher, clinical pregnancy rates per OPU (37.5 %) and embryo transfer (38.4 %) were superior in comparison to Group B (27.0 %, P = 0.013; 29.4 %, P = 0.041; respectively). On the other hand, implantation rates (Group A, 23.7 %; Group B, 20.8 %) and proportions of babies born per transferred embryo (Group A, 19.5 %; Group B, 16.9 %) were similar (P = 0.528 and 0.332, respectively). CONCLUSIONS: Overall, this suggests that oocyte competence is already achieved at the antral stage of follicle development.
Authors: F J Ectors; P Vanderzwalmen; J Van Hoeck; M Nijs; G Verhaegen; A Delvigne; R Schoysman; F Leroy Journal: Hum Reprod Date: 1997-09 Impact factor: 6.918
Authors: Mariabeatrice Dal Canto; Fausta Brambillasca; Mario Mignini Renzini; Giovanni Coticchio; Maria Merola; Monia Lain; Elena De Ponti; Rubens Fadini Journal: J Assist Reprod Genet Date: 2012-04-18 Impact factor: 3.412
Authors: R Fadini; M B Dal Canto; M Mignini Renzini; F Brambillasca; R Comi; D Fumagalli; M Lain; M Merola; R Milani; E De Ponti Journal: Reprod Biomed Online Date: 2009-09 Impact factor: 3.828
Authors: Rubens Fadini; Mario Mignini Renzini; Teresa Guarnieri; Mariabeatrice Dal Canto; Elena De Ponti; Alastair Sutcliffe; Mark Shevlin; Ruggero Comi; Giovanni Coticchio Journal: Hum Reprod Date: 2012-10-04 Impact factor: 6.918