Dazhi Fan1, Li Liu1, Ning Ding1, Si Liu1, Yanting Hu1, Guoqi Cai1, Guo Xia1, Lihong Xin1, Li Wang1, Shengqian Xu1, Jianhua Xu1, Yanfeng Zou1, Faming Pan2. 1. From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University. 2. From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University. famingpan@ahmu.edu.cn.
Abstract
OBJECTIVE: No consensus has been reached on sexual dysfunction in men with ankylosing spondylitis (AS). Our study aimed to derive a more precise estimation of the sexual function and its clinical correlations in men with AS. METHODS: A metaanalysis was performed and the related literature were searched in PubMed, Elsevier Science Direct, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and in reference lists of articles and systematic reviews. Score of the International Index of Erectile Function (IIEF) was used as the outcome measurement, and standardized mean differences (SMD) with 95% CI were calculated. RESULTS: Eleven studies were included, including 535 men with AS and 430 male controls. Each domain of the IIEF score (erectile function: SMD -0.52, 95% CI -0.68 - -0.37; orgasmic function: -0.72, -1.03 - -0.42; sexual drive: -0.40, -0.62 - -0.18; intercourse satisfaction: -0.86, -1.15 - -0.56; and overall satisfaction: -0.61, -0.91 - -0.32) were lower in men with AS than in controls. In the subgroup analysis, the results did not change except for the sexual drive in the Asians group (-0.15, -0.42-0.13). At metaregression, no study characteristics were significantly associated with effect size of the IIEF score. CONCLUSION: Sexual function is impaired in male patients with AS and further studies are necessary to better understand risk factors for sexual dysfunction in this population.
OBJECTIVE: No consensus has been reached on sexual dysfunction in men with ankylosing spondylitis (AS). Our study aimed to derive a more precise estimation of the sexual function and its clinical correlations in men with AS. METHODS: A metaanalysis was performed and the related literature were searched in PubMed, Elsevier Science Direct, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and in reference lists of articles and systematic reviews. Score of the International Index of Erectile Function (IIEF) was used as the outcome measurement, and standardized mean differences (SMD) with 95% CI were calculated. RESULTS: Eleven studies were included, including 535 men with AS and 430 male controls. Each domain of the IIEF score (erectile function: SMD -0.52, 95% CI -0.68 - -0.37; orgasmic function: -0.72, -1.03 - -0.42; sexual drive: -0.40, -0.62 - -0.18; intercourse satisfaction: -0.86, -1.15 - -0.56; and overall satisfaction: -0.61, -0.91 - -0.32) were lower in men with AS than in controls. In the subgroup analysis, the results did not change except for the sexual drive in the Asians group (-0.15, -0.42-0.13). At metaregression, no study characteristics were significantly associated with effect size of the IIEF score. CONCLUSION: Sexual function is impaired in male patients with AS and further studies are necessary to better understand risk factors for sexual dysfunction in this population.
Entities:
Keywords:
ANKYLOSING SPONDYLITIS; MEN; METAANALYSIS; SEXUAL DYSFUNCTION