Literature DB >> 25448698

The ABC transporter, AbcB3, mediates cAMP export in D. discoideum development.

Edward Roshan Miranda1, Edward A Nam2, Adam Kuspa3, Gad Shaulsky4.   

Abstract

Extracellular cAMP functions as a primary ligand for cell surface cAMP receptors throughout Dictyostelium discoideum development, controlling chemotaxis and morphogenesis. The developmental consequences of cAMP signaling and the metabolism of cAMP have been studied in great detail, but it has been unclear how cells export cAMP across the plasma membrane. Here we show pharmacologically and genetically that ABC transporters mediate cAMP export. Using an evolutionary-developmental biology approach, we identified several candidate abc genes and characterized one of them, abcB3, in more detail. Genetic and biochemical evidence suggest that AbcB3 is a component of the cAMP export mechanism in D. discoideum development.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ATP-binding cassette transporters; Dictyostelium; cAMP

Mesh：

Substances：

Year:  2014        PMID： 25448698      PMCID： PMC4277735          DOI： 10.1016/j.ydbio.2014.11.006

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


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