| Literature DB >> 25448678 |
Yuko Maejima1, Kazuya Sakuma2, Putra Santoso2, Darambazar Gantulga2, Kenichi Katsurada2, Yoichi Ueta3, Yuichi Hiraoka4, Katsuhiko Nishimori4, Shigeyasu Tanaka5, Kenju Shimomura1, Toshihiko Yada6.
Abstract
Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin-dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus. Intra-ARC injection of Oxt decreased food intake. Oxt increased cytosolic Ca(2+) in POMC neurons isolated from ARC. ARC POMC neurons expressed Oxt receptors and were contacted by Oxt terminals. Retrograde tracer study revealed the projection of PVN and SON Oxt neurons to ARC. These results demonstrate the novel oxytocinergic signaling from PVN/SON to ARC POMC, possibly regulating feeding.Entities:
Keywords: Arcuate nucleus; Feeding; Obesity; Oxytocin; Proopiomelanocortin
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Year: 2014 PMID： 25448678 DOI： 10.1016/j.febslet.2014.10.010
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124