Mong-Loon Kuet1, Anand V Kasbekar2, Liam Masterson1, Piyush Jani1. 1. Department of Otolaryngology-Head and Neck Surgery, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United Kingdom. 2. Department of Otolaryngology-Head and Neck Surgery, Aintree University Hospital, Liverpool, United Kingdom.
Abstract
OBJECTIVES: We present a systematic review of 1,252 lesions published in the past 25 years, the largest to date. We also include our own experience of 41 cases. DATA SOURCES: Our data sources were MEDLINE and Embase databases. REVIEW METHODS: A systematic review of the literature (1988-2014) was performed and data on histological diagnosis, presentation, surgical approach, and postoperative complications were reviewed. RESULTS: In total, 22 studies (including our own institution) revealed 82% of lesions were benign. The most common presentation was an intraoral mass (52%) followed by a cervical mass (48%), and the most common primary lesion was a pleomorphic adenoma (29%). Ninety-six percent of patients underwent surgery. The cervical approach was most frequently used (46%), and the most common complication was vagus nerve injury (13%). Within our institution, 5-year progression-free survival for benign and malignant disease was 93% and 61%, respectively (P = .196). CONCLUSIONS: A parapharyngeal space mass is an uncommon tumor and requires careful preoperative assessment. Definitive treatment is usually surgery, and these patients should be counseled appropriately about the potential for permanent cranial nerve deficits. LEVEL OF EVIDENCE: NA.
OBJECTIVES: We present a systematic review of 1,252 lesions published in the past 25 years, the largest to date. We also include our own experience of 41 cases. DATA SOURCES: Our data sources were MEDLINE and Embase databases. REVIEW METHODS: A systematic review of the literature (1988-2014) was performed and data on histological diagnosis, presentation, surgical approach, and postoperative complications were reviewed. RESULTS: In total, 22 studies (including our own institution) revealed 82% of lesions were benign. The most common presentation was an intraoral mass (52%) followed by a cervical mass (48%), and the most common primary lesion was a pleomorphic adenoma (29%). Ninety-six percent of patients underwent surgery. The cervical approach was most frequently used (46%), and the most common complication was vagus nerve injury (13%). Within our institution, 5-year progression-free survival for benign and malignant disease was 93% and 61%, respectively (P = .196). CONCLUSIONS: A parapharyngeal space mass is an uncommon tumor and requires careful preoperative assessment. Definitive treatment is usually surgery, and these patients should be counseled appropriately about the potential for permanent cranial nerve deficits. LEVEL OF EVIDENCE: NA.
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