| Literature DB >> 25448581 |
Zdenka Bujňáková1, Erika Dutková2, Matej Baláž2, Erika Turianicová2, Peter Baláž2.
Abstract
In this paper the stability of the arsenic sulfide (As4S4) nanosuspension prepared by wet milling in a circulation mill in the environment of copolymer Poloxamer 407 was studied. The obtained As4S4 particles in nanosuspension were of ∼ 100 nm in size. The influence of temperature and UV irradiation on the changes in physical and/or chemical properties was followed. Long-term stability was observed via particle size distribution and zeta potential measurements. Influence of UV irradiation was studied via UV-vis spectroscopy (UV-vis), photoluminicsence (PL) technique and Fourier transform infrared spectroscopy (FTIR) measurements. The best stability of the nanosuspension (24 weeks) was achieved when stored at 4°C and in the dark.Entities:
Keywords: Arsenic sulfide; Nanomilling; Nanosuspension; Particle size; Stability
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Year: 2014 PMID： 25448581 DOI： 10.1016/j.ijpharm.2014.11.043
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875