Ling Feng1, Xueping Chen1, Shujie Liu1, Zengrong Zhou1, Rong Yang2. 1. Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, China. 2. Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, China. Electronic address: 441607140@qq.com.
Abstract
BACKGROUND: On September 22, 2013, two patients from Sichuan Province, China presented with symptoms of food-borne botulism, a rare but fatal illness caused by the consumption of foods containing Clostridium botulinum neurotoxins. METHODS: Investigators reviewed the medical charts and food consumption histories, and interviewed patients and family members. Food samples and clinical specimens were tested for botulinum toxin and neurotoxin-producing Clostridium species by standard methods. RESULTS: The first two index cases presented with cranial neuropathies and flaccid paralysis, and required mechanical ventilation. There were 12 confirmed outbreak-associated cases. Botulinum toxin type A was identified in the smoked ribs, and all of the patients had consumed the smoked ribs from the same local restaurant. The smoked ribs contained no added salt, sugar, or preservative. Botulinum toxin production likely resulted from the cold-smoking preparation method and inappropriate refrigeration. CONCLUSIONS: Smoked ribs produced by a local restaurant, contaminated with type A botulism, was the contributor to this outbreak. The supervision of food safety should be strengthened to prevent future outbreaks in China.
BACKGROUND: On September 22, 2013, two patients from Sichuan Province, China presented with symptoms of food-borne botulism, a rare but fatal illness caused by the consumption of foods containing Clostridiumbotulinum neurotoxins. METHODS: Investigators reviewed the medical charts and food consumption histories, and interviewed patients and family members. Food samples and clinical specimens were tested for botulinum toxin and neurotoxin-producing Clostridium species by standard methods. RESULTS: The first two index cases presented with cranial neuropathies and flaccid paralysis, and required mechanical ventilation. There were 12 confirmed outbreak-associated cases. Botulinum toxin type A was identified in the smoked ribs, and all of the patients had consumed the smoked ribs from the same local restaurant. The smoked ribs contained no added salt, sugar, or preservative. Botulinum toxin production likely resulted from the cold-smoking preparation method and inappropriate refrigeration. CONCLUSIONS: Smoked ribs produced by a local restaurant, contaminated with type A botulism, was the contributor to this outbreak. The supervision of food safety should be strengthened to prevent future outbreaks in China.
Authors: John C O'Horo; Eugene P Harper; Abdelghani El Rafei; Rashid Ali; Daniel C DeSimone; Amra Sakusic; Omar M Abu Saleh; Jasmine R Marcelin; Eugene M Tan; Agam K Rao; Jeremy Sobel; Pritish K Tosh Journal: Clin Infect Dis Date: 2017-12-27 Impact factor: 9.079
Authors: Tinh Huu Ho; Ha Phan Ai Nguyen; Nhan Dinh Trong Le; Phuong Hoai Hoang; Ninh Thi Ha; Chinh Van Dang Journal: Western Pac Surveill Response J Date: 2022-01-06