BACKGROUND: In this study we report on the outcome including overall and cause-specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality. METHODS: Two hundred thirty-seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow-up period of up to 38 years. Overall and cause-specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated. RESULTS AND CONCLUSION: Two hundred thirty patients had died by December 31, 2012; a total of 3,489 person-years were available for observation. The SMR at 38 years of follow-up was 2.02 (1.76-2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause-specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases.
BACKGROUND: In this study we report on the outcome including overall and cause-specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality. METHODS: Two hundred thirty-seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow-up period of up to 38 years. Overall and cause-specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated. RESULTS AND CONCLUSION: Two hundred thirty patients had died by December 31, 2012; a total of 3,489 person-years were available for observation. The SMR at 38 years of follow-up was 2.02 (1.76-2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause-specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases.
Authors: Kirsten M Anderson; Danillo G Augusto; Ravi Dandekar; Hengameh Shams; Chao Zhao; Tasneem Yusufali; Gonzalo Montero-Martín; Wesley M Marin; Neda Nemat-Gorgani; Lisa E Creary; Stacy Caillier; Mohammad R K Mofrad; Peter Parham; Marcelo Fernández-Viña; Jorge R Oksenberg; Paul J Norman; Jill A Hollenbach Journal: J Immunol Date: 2020-07-24 Impact factor: 5.422
Authors: Paulo Bugalho; Filipa Ladeira; Raquel Barbosa; João Pedro Marto; Claudia Borbinha; Manuel Salavisa; Laurete da Conceição; Marlene Saraiva; Marco Fernandes; Bruna Meira Journal: J Neural Transm (Vienna) Date: 2019-08-05 Impact factor: 3.575