| Literature DB >> 25447599 |
Chiara Briani1, Chiara Dalla Torre2, Federica Lessi3, Tiziana Cavallaro4, Marina Scarlato5, Sergio Ferrari4, Marta Campagnolo2, Marta Lucchetta2, Ilaria Cabrini4, Michela Morbin6, Giuseppe Lauria6, Fausto Adami3, Angelo A Manfredi7.
Abstract
Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 was also assessed (immunohistochemistry) on sural nerve biopsies from POEMS and vasculitic neuropathy patients. No correlation was found between PTX3 and VEGF levels in POEMS or controls. Sural nerve biopsies from vasculitic neuropathy patients, but not those from POEMS syndrome, showed strong PTX3 staining. PTX3, expression of vessel inflammation/remodeling, and VEGF, crucial pro-angiogenic cytokine, appear to be independently regulated in POEMS syndrome.Entities:
Keywords: POEMS syndrome; Pentraxin 3; Polyneuropathy; Vascular endothelial growth factor (VEGF); Vasculitis
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Year: 2014 PMID： 25447599 DOI： 10.1016/j.jneuroim.2014.09.021
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478