Literature DB >> 25447537

α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin.

Bethany C Prudner1, Pritam Sinha Roy2, Derek S Damron3, Mary A Russell4.   

Abstract

α-Synemin contains a unique 312 amino acid insert near the end of its C-terminal tail. Therefore we set out to determine if the insert is a site of protein-protein interaction that regulates the sub-cellular localization of this large isoform of synemin. Yeast-two hybrid analysis indicated that this region is a binding site for the M10 region of titin. This was confirmed with GST pull-down assays. Co-immunoprecipitation of endogenous proteins indicated close association of the two proteins in vivo and immunostaining of cardiomyocytes demonstrated co-localization of the proteins at the M-band of the sarcomere.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  A-kinase anchoring protein; Cytoskeleton; Intermediate filament; Protein kinase A; Signal transduction; Synemin

Mesh：

Substances：

Year:  2014        PMID： 25447537      PMCID： PMC4268398          DOI： 10.1016/j.febslet.2014.11.001

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  50 in total

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5.  Pairwise sequence similarity mapping with PaSiMap: Reclassification of immunoglobulin domains from titin as case study.

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