Maud Guivarc'h1, Ugo Ordioni2, Jean-Hugues Catherine1, Fabrice Campana3, Jean Camps4, Frédéric Bukiet5. 1. UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; UMR 7268 ADES Aix-Marseille Université-EFS-CNRS, Faculté de Médecine de Marseille, Marseille, France. 2. UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; Centre Massilien de la Face, Marseille, France. 3. Centre Massilien de la Face, Marseille, France. 4. UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France. 5. UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; Laboratoire Biologie Santé et Nanosciences, UFR Odontologie de Montpellier 1, Montpellier, France. Electronic address: frederic.bukiet@univ-amu.fr.
Abstract
INTRODUCTION: Sinus aspergillosis is a potential complication after root canal therapy of antral teeth. Indeed, zinc oxide-eugenol cement overfilling in the sinus may promote fungal infection. Moreover, if sinus aspergillosis triggers chronic sinusitis with aspergilloma, it may also lead to invasive phenomena, especially for immunocompromised patients. METHODS: We reported a sinus aspergillosis case of a patient treated with infliximab (Remicade; Janssen Biologics BV, Leiden, Netherlands). The purpose of this article was to explore the mechanisms of this pathosis, especially the impact of the root canal sealer overextension, which is a contributing factor for fungal infection. The surgical management and the follow-up are also described. RESULTS: Six months after surgery, the patient showed no clinical signs and presented with a healthy and airy right maxillary sinus on the computed tomography scan. CONCLUSIONS: In conclusion, prevention and screening of aspergillosis of maxillary sinus may be considered before starting an anti-tumor necrosis factor alpha therapy.
INTRODUCTION:Sinus aspergillosis is a potential complication after root canal therapy of antral teeth. Indeed, zinc oxide-eugenol cement overfilling in the sinus may promote fungal infection. Moreover, if sinus aspergillosis triggers chronic sinusitis with aspergilloma, it may also lead to invasive phenomena, especially for immunocompromised patients. METHODS: We reported a sinus aspergillosis case of a patient treated with infliximab (Remicade; Janssen Biologics BV, Leiden, Netherlands). The purpose of this article was to explore the mechanisms of this pathosis, especially the impact of the root canal sealer overextension, which is a contributing factor for fungal infection. The surgical management and the follow-up are also described. RESULTS: Six months after surgery, the patient showed no clinical signs and presented with a healthy and airy right maxillary sinus on the computed tomography scan. CONCLUSIONS: In conclusion, prevention and screening of aspergillosis of maxillary sinus may be considered before starting an anti-tumor necrosis factor alpha therapy.