Literature DB >> 25447414

The protective effect of apelin on ischemia/reperfusion injury.

Yanjie Yang1, Shuang-Yu Lv2, Shuang-Kun Lyu3, Dongdong Wu1, Qiang Chen4.   

Abstract

Apelin is the endogenous ligand for the APJ, a member of the G protein coupled receptors family. Apelin/APJ system is widely distributed in central nervous system and peripheral tissues, especially in heart, lung and kidney. Apelin plays important physiological and pathological roles in cardiovascular system, immune system, neuroprotection, etc. This article outlines the protective effect of apelin on ischemia/reperfusion (I/R) injury. Apelin could activate multiple protective mechanisms to prevent heart, brain, liver and kidney I/R injury. Apelin/APJ system may be a promising therapeutic target for ischemic and other related diseases.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  APJ; Apelin; Brain; Heart; Ischemia/reperfusion injury

Mesh：

Substances：

Year:  2014        PMID： 25447414     DOI： 10.1016/j.peptides.2014.11.001

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  14 in total

1.  Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth.

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Journal:  Cancer Lett       Date:  2016-11-26       Impact factor: 8.679

2.  Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.

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Journal:  Neurochem Res       Date:  2016-03-09       Impact factor: 3.996

3.  MiRNA-122-5p inhibitor abolishes angiotensin II-mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the apelin-AMPK-mTOR signaling.

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Journal:  In Vitro Cell Dev Biol Anim       Date:  2022-02-07       Impact factor: 2.416

Review 4.  Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo.

Authors:  Stefano Morara; Anna Maria Colangelo; Luciano Provini
Journal:  Neural Plast       Date:  2015-07-26       Impact factor: 3.599

5.  Load-dependent effects of apelin on murine cardiomyocytes.

Authors:  Rémi Peyronnet; Christian Bollensdorff; Rebecca A Capel; Eva A Rog-Zielinska; Christopher E Woods; David N Charo; Oleg Lookin; Giovanni Fajardo; Michael Ho; Thomas Quertermous; Euan A Ashley; Peter Kohl
Journal:  Prog Biophys Mol Biol       Date:  2017-09-18       Impact factor: 3.667

6.  Can apelin play a role in the etiology of tinnitus?

Authors:  Nuray Ensari; Özer Erdem Gür; Nilgün Gür; Ömer Tarık Selçuk; Levent Renda; Mustafa Deniz Yılmaz; Mehmet Türker Öztürk; Yeşim Çekin
Journal:  Turk J Med Sci       Date:  2019-06-18       Impact factor: 0.973

Review 7.  Leptomeningeal anastomoses: Mechanisms of pial collateral remodeling in ischemic stroke.

Authors:  Alexandra M Kaloss; Michelle H Theus
Journal:  WIREs Mech Dis       Date:  2022-02-03

8.  In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope.

Authors:  Tijana Bojić; Vladimir R Perović; Sanja Glišić
Journal:  Front Neurosci       Date:  2016-01-21       Impact factor: 4.677

Review 9.  Apelin/APJ system: A key therapeutic target for liver disease.

Authors:  Shuang-Yu Lv; Binbin Cui; Wei-Dong Chen; Yan-Dong Wang
Journal:  Oncotarget       Date:  2017-12-01

10.  Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.

Authors:  Xia Zhang; Mengping Wei; Jiahui Fan; Weijie Yan; Xu Zha; Huimeng Song; Rongqi Wan; Yanling Yin; Wei Wang
Journal:  Autophagy       Date:  2020-11-12       Impact factor: 16.016
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