| Literature DB >> 25447315 |
Abstract
Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity.Entities:
Keywords: BRCA2; Cell cycle; HDR (homology-directed recombination); Replication fork; Spindle assembly checkpoint (SAC)
Mesh：
Substances：
Year: 2014 PMID： 25447315 DOI： 10.1016/j.yexcr.2014.10.008
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905