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Literature DB >> 25447243

Gram-positive antimicrobial activity of amino acid-based hydrogels.

I Irwansyah¹, Yong-Qiang Li, Wenxiong Shi, Dianpeng Qi, Wan Ru Leow, Mark B Y Tang, Shuzhou Li, Xiaodong Chen.

Abstract

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.

Entities: Chemical Species

Keywords: Fmoc-amino acids; antimicrobial hydrogels; biocompatible; co-assembly; gram-positive bacteria

Mesh：

Substances：

Year: 2014 PMID： 25447243 DOI： 10.1002/adma.201403339

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

18 in total

Review 1. Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

Authors: Xuewen Du; Jie Zhou; Junfeng Shi; Bing Xu
Journal: Chem Rev Date: 2015-12-08 Impact factor: 60.622

Review 2. Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.

Authors: Jiaul Hoque; Nivedita Sangaj; Shyni Varghese
Journal: Macromol Biosci Date: 2018-10-08 Impact factor: 4.979

3. Amino Acid Based Self-assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks.

Authors: Priyadarshi Chakraborty; Ehud Gazit
Journal: ChemNanoMat Date: 2018-08 Impact factor: 3.154

4. Biomaterial-based delivery of antimicrobial therapies for the treatment of bacterial infections.

Authors: Pranav P Kalelkar; Milan Riddick; Andrés J García
Journal: Nat Rev Mater Date: 2021-09-15 Impact factor: 66.308

5. 1-(2-aminophenyl)-1H-1,2,3-triazole-4-carboxylic acid: activity against Gram-positive and Gram-negative pathogens including Vibrio cholerae.

Authors: Krishnendu Maji; Debasish Haldar
Journal: R Soc Open Sci Date: 2017-10-18 Impact factor: 2.963

Gram-positive antimicrobial activity of amino acid-based hydrogels.

Review 1. Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

Review 2. Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.

3. Amino Acid Based Self-assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks.

4. Biomaterial-based delivery of antimicrobial therapies for the treatment of bacterial infections.

5. 1-(2-aminophenyl)-1H-1,2,3-triazole-4-carboxylic acid: activity against Gram-positive and Gram-negative pathogens including Vibrio cholerae.

6. Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.

Review 7. Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails.

Review 8. Antiviral Nanomaterials for Designing Mixed Matrix Membranes.

9. Cation Tuning toward the Inference of the Gelation Behavior of Supramolecular Gels.

10. Anthranilamide-based Short Peptides Self-Assembled Hydrogels as Antibacterial Agents.