Arenda J W Haasnoot1, Maretta van Tent-Hoeve2, Nico M Wulffraat3, Nicoline E Schalij-Delfos4, Leonoor I Los5, Wineke Armbrust6, Nicolaas P A Zuithoff7, Joke H de Boer2. 1. Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands. Electronic address: a.j.w.haasnoot@umcutrecht.nl. 2. Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands. 3. Department of Pediatric Rheumatology, Utrecht University Medical Center, Wilhelmina Children's Hospital, Utrecht, Netherlands. 4. Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands. 5. Department of Ophthalmology, Groningen University Medical Center, Groningen, Netherlands. 6. Department of Pediatric Rheumatology, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, Netherlands. 7. Department of Biostatistics and Research Support, Julius Center, Utrecht University Medical Center, Utrecht, Netherlands.
Abstract
PURPOSE: To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. DESIGN: Retrospective cohort study. METHODS: In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis. RESULTS: One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed. CONCLUSIONS: Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
PURPOSE: To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. DESIGN: Retrospective cohort study. METHODS: In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of humanleukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis. RESULTS: One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed. CONCLUSIONS: Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
Authors: Mikel Alberdi-Saugstrup; Marek Zak; Susan Nielsen; Troels Herlin; Ellen Nordal; Lillemor Berntson; Anders Fasth; Marite Rygg Journal: Rheumatol Int Date: 2017-03-10 Impact factor: 2.631
Authors: Anne-Mieke J W Haasnoot; Lenneke A Vernie; Aniki Rothova; Patricia V D Doe; Leonoor I Los; Nicoline E Schalij-Delfos; Joke H de Boer Journal: PLoS One Date: 2016-10-10 Impact factor: 3.240
Authors: Sheila T Angeles-Han; Steven Yeh; Purnima Patel; Duc Duong; Kirsten Jenkins; Kelly A Rouster-Stevens; Mekibib Altaye; Ndate Fall; Sherry Thornton; Sampath Prahalad; Gary N Holland Journal: J Ophthalmic Inflamm Infect Date: 2018-10-16