Gerald Seidel1, Silke Hausberger2, Sereina Annik Herzog3, Stefan Palkovits2, Eva Maria Pöschl2, Werner Wackernagel2, Martin Weger2. 1. Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria. Electronic address: gerald.seidel@medunigraz.at. 2. Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria. 3. Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz/Austria, Graz, Austria.
Abstract
PURPOSE: To investigate a potential circadian fluctuation of the choroidal volume in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective observational case series. METHODS: Thirty healthy eyes of 15 healthy subjects with a median age of 26 years (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement every 3 hours within a 24-hour period at a single tertiary center. The mean ocular perfusion pressure was calculated for each eye at each of the 8 time points as 2/3(mean arterial pressure-intraocular pressure [IOP]). The circadian fluctuation of the macular choroidal volume as well as the association with axial length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed model. RESULTS: Macular choroidal volume showed a significant circadian fluctuation (P < .05) and was lowest at midday (mean ± SD, 10.14 ± 2.62 mm(3)) and highest at 3 AM (mean ± SD, 10.66 ± 2.70 mm(3)). Of all factors tested, only mean ocular perfusion pressure showed a significant association with macular choroidal volume fluctuation (P = .016). CONCLUSIONS: Macular choroidal volume shows a significant circadian pattern with higher values at night and lower values during the day in young adults. Besides time, mean ocular perfusion pressure is significantly associated with this fluctuation.
PURPOSE: To investigate a potential circadian fluctuation of the choroidal volume in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective observational case series. METHODS: Thirty healthy eyes of 15 healthy subjects with a median age of 26 years (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement every 3 hours within a 24-hour period at a single tertiary center. The mean ocular perfusion pressure was calculated for each eye at each of the 8 time points as 2/3(mean arterial pressure-intraocular pressure [IOP]). The circadian fluctuation of the macular choroidal volume as well as the association with axial length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed model. RESULTS: Macular choroidal volume showed a significant circadian fluctuation (P < .05) and was lowest at midday (mean ± SD, 10.14 ± 2.62 mm(3)) and highest at 3 AM (mean ± SD, 10.66 ± 2.70 mm(3)). Of all factors tested, only mean ocular perfusion pressure showed a significant association with macular choroidal volume fluctuation (P = .016). CONCLUSIONS: Macular choroidal volume shows a significant circadian pattern with higher values at night and lower values during the day in young adults. Besides time, mean ocular perfusion pressure is significantly associated with this fluctuation.
Authors: Caio V Regatieri; Eduardo A Novais; Lauren Branchini; Mehreen Adhi; Emily D Cole; Ricardo Louzada; Mark Lane; Elias Reichel; Jay S Duker Journal: Int J Retina Vitreous Date: 2016-09-15
Authors: Wilfried Glatz; Gernot Steinwender; Lisa Tarmann; Eva Maria Malle; Marlene Schörkhuber; Werner Wackernagel; Goran Petrovski; Andreas Wedrich; Domagoj Ivastinovic Journal: PLoS One Date: 2017-12-15 Impact factor: 3.240