| Literature DB >> 2544674 |
M Y Liu1, W H Chou, L Nutter, M M Hsu, J Y Chen, C S Yang.
Abstract
A salt-dependent DNA polymerase activity was demonstrated in the culture of an EBV-producing, lymphoblastoid cell line (NPC-204 cells) treated with 5-iodo-2'-deoxyuridine (IUdR). There was a high frequency of levels of antibody to this enzyme in sera of patients with nasopharyngeal carcinoma (NPC). In contrast, sera from healthy subjects had little or no neutralizing activity. The high antibody level appeared as early as stage 1 of the disease in many NPC patients. The levels of the antibody increased with the progression of the disease and declined in treated patients. The results strongly suggest that tests measuring serum antibody against EBV DNA polymerase activity can be used for early diagnosis and prognosis of NPC.Entities:
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Year: 1989 PMID： 2544674 DOI： 10.1002/jmv.1890280209
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327