BACKGROUND: There are no specific recommendations for the design and reporting of studies of children with fever and neutropenia (FN). As a result, there is marked heterogeneity in the variables and outcomes that are reported and new definitions continue to emerge. These inconsistencies hinder the ability of researchers and clinicians to compare, contrast and combine results. The objective was to achieve expert consensus on a core set of variables and outcomes that should be measured and reported, as a minimum, in pediatric FN studies. PROCEDURE: The Delphi method was used to achieve consensus among an international group of clinicians, pharmacists, researchers, and patient representatives. Four surveys focusing on (i) the identification of a core set of variables and outcomes; and (ii) definitions of these variables and outcomes, were administered electronically. Consensus was predefined as more than 80% agreement on any statement. RESULTS: There were forty-five survey participants and the response rate ranged between 84 and 96%. There was consensus on eight core variables and 10 core outcomes that should be collected and reported in all studies of children with FN. Consensus definitions were identified for all of the core outcomes. CONCLUSION: Using the Delphi method, expert consensus on a set of core variables and outcomes, and their corresponding definitions, was achieved. These core sets represent the minimum that should be collected and reported in all studies of children with FN. This will promote collaboration and ensure consistency and comparability between studies.
BACKGROUND: There are no specific recommendations for the design and reporting of studies of children with fever and neutropenia (FN). As a result, there is marked heterogeneity in the variables and outcomes that are reported and new definitions continue to emerge. These inconsistencies hinder the ability of researchers and clinicians to compare, contrast and combine results. The objective was to achieve expert consensus on a core set of variables and outcomes that should be measured and reported, as a minimum, in pediatric FN studies. PROCEDURE: The Delphi method was used to achieve consensus among an international group of clinicians, pharmacists, researchers, and patient representatives. Four surveys focusing on (i) the identification of a core set of variables and outcomes; and (ii) definitions of these variables and outcomes, were administered electronically. Consensus was predefined as more than 80% agreement on any statement. RESULTS: There were forty-five survey participants and the response rate ranged between 84 and 96%. There was consensus on eight core variables and 10 core outcomes that should be collected and reported in all studies of children with FN. Consensus definitions were identified for all of the core outcomes. CONCLUSION: Using the Delphi method, expert consensus on a set of core variables and outcomes, and their corresponding definitions, was achieved. These core sets represent the minimum that should be collected and reported in all studies of children with FN. This will promote collaboration and ensure consistency and comparability between studies.
Authors: Christa Koenig; Christine Schneider; Jessica E Morgan; Roland A Ammann; Lillian Sung; Bob Phillips Journal: Support Care Cancer Date: 2019-07-01 Impact factor: 3.603
Authors: Gabrielle M Haeusler; Alexandra L Garnham; Connie Sn Li-Wai-Suen; Julia E Clark; Franz E Babl; Zoe Allaway; Monica A Slavin; Francoise Mechinaud; Gordon K Smyth; Bob Phillips; Karin A Thursky; Marc Pellegrini; Marcel Doerflinger Journal: Clin Transl Immunology Date: 2022-05-17
Authors: Miriam L Gonzalez; Paula Aristizabal; Adriana Loera-Reyna; Dara Torres; Mario Ornelas-Sánchez; Laura Nuño-Vázquez; Marco Aguilera; Alicia Sánchez; Mitzy Romano; Rebeca Rivera-Gómez; George Relyea; Paola Friedrich; Miguela A Caniza Journal: JCO Glob Oncol Date: 2021-05
Authors: Arne Simon; Rhoikos Furtwängler; Norbert Graf; Hans Jürgen Laws; Sebastian Voigt; Brar Piening; Christine Geffers; Philipp Agyeman; Roland A Ammann Journal: GMS Hyg Infect Control Date: 2016-05-12
Authors: Gabrielle M Haeusler; Karin A Thursky; Francoise Mechinaud; Franz E Babl; Richard De Abreu Lourenco; Monica A Slavin; Robert Phillips Journal: Br J Cancer Date: 2017-06-13 Impact factor: 7.640
Authors: Robert S Phillips; Lillian Sung; Roland A Ammann; Richard D Riley; Elio Castagnola; Gabrielle M Haeusler; Robert Klaassen; Wim J E Tissing; Thomas Lehrnbecher; Julia Chisholm; Hana Hakim; Neil Ranasinghe; Marianne Paesmans; Ian M Hann; Lesley A Stewart Journal: Br J Cancer Date: 2016-03-08 Impact factor: 7.640