| Literature DB >> 25446398 |
Arij Ben Chaaben1, Christina Mariaselvam, Sofiane Salah, Marc Busson, Nicolas Dulphy, Hayet Douik, Abderraouf Ghanem, Wahid Boukaouci, Reem Al Daccak, Tesnim Mamoghli, Latifa Harzallah, Jihene Bouassida, Catherine Fortier, Said Gritli, Jeannette Ben Hamida, Dominique Charron, Rajagopal Krishnamoorthy, Fethi Guemira, Ryad Tamouza.
Abstract
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.Entities:
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Year: 2015 PMID： 25446398 DOI： 10.1016/j.imbio.2014.09.021
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144