Hui-Jun Yang1, Young Eun Kim2, Ji Young Yun3, Gwanhee Ehm4, Han-Joon Kim4, Beom Seok Jeon5. 1. Department of Neurology, Ulsan University Hospital, Ulsan, Republic of Korea. 2. Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea. 3. Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea. 4. Department of Neurology and Movement Disorder Center, Parkinson's Disease Study Group and Neuroscience Research Institute, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, Republic of Korea. 5. Department of Neurology and Movement Disorder Center, Parkinson's Disease Study Group and Neuroscience Research Institute, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, Republic of Korea. Electronic address: brain@snu.ac.kr.
Abstract
BACKGROUND: SWEDDs (Scans Without Evidence of Dopaminergic Deficits) was defined from a series of pharmaceutical trials on Parkinson's disease (PD). Non-motor features including sleep-related problems are common even in early-stage PD patients; however, little is known about the burden of the non-motor symptoms in SWEDDs patients. METHODS: The Non-motor Symptoms Assessment Scale (NMSS), revised version of the Parkinson's Disease Sleep Scale (PDSS-2), Epworth Sleepiness Scale (ESS), and EuroQol 5-Dimension (EQ-5D) were applied to evaluate 17 SWEDDs patients and 28 de novo PD patients. The presence of clinically probable rapid eye movement sleep behavior disorder (cpRBD) was assessed using the International Classification of Sleep Disorders-Revised (ICSD-R) criteria. RESULTS: The total NMSS score for the SWEDDs group was significantly lower than for the de novo PD group (p = 0.032). The most distinct difference was in taste or smell change (p < 0.000). Prevalence of cpRBD was higher in de novo PD patients than in SWEDDs patients (p = 0.030), though no significant differences in the PDSS-2 total score (p = 0.496) or the ESS score (p = 0.517) were found. The SWEDDs patients did not significantly differ from the de novo PD patients with regard to quality of life, as measured by the EQ-5D index score (p = 0.177). CONCLUSIONS: The patients with SWEDDs have less non-motor problems than newly diagnosed untreated PD patients. Given the difficulty distinguishing between SWEDDs and early PD, identifying some of non-motor symptoms, such as RBD or olfactory impairment, could aid clinicians in their work.
BACKGROUND: SWEDDs (Scans Without Evidence of Dopaminergic Deficits) was defined from a series of pharmaceutical trials on Parkinson's disease (PD). Non-motor features including sleep-related problems are common even in early-stage PDpatients; however, little is known about the burden of the non-motor symptoms in SWEDDs patients. METHODS: The Non-motor Symptoms Assessment Scale (NMSS), revised version of the Parkinson's Disease Sleep Scale (PDSS-2), Epworth Sleepiness Scale (ESS), and EuroQol 5-Dimension (EQ-5D) were applied to evaluate 17 SWEDDs patients and 28 de novo PDpatients. The presence of clinically probable rapid eye movement sleep behavior disorder (cpRBD) was assessed using the International Classification of Sleep Disorders-Revised (ICSD-R) criteria. RESULTS: The total NMSS score for the SWEDDs group was significantly lower than for the de novo PD group (p = 0.032). The most distinct difference was in taste or smell change (p < 0.000). Prevalence of cpRBD was higher in de novo PDpatients than in SWEDDs patients (p = 0.030), though no significant differences in the PDSS-2 total score (p = 0.496) or the ESS score (p = 0.517) were found. The SWEDDs patients did not significantly differ from the de novo PDpatients with regard to quality of life, as measured by the EQ-5D index score (p = 0.177). CONCLUSIONS: The patients with SWEDDs have less non-motor problems than newly diagnosed untreated PDpatients. Given the difficulty distinguishing between SWEDDs and early PD, identifying some of non-motor symptoms, such as RBD or olfactory impairment, could aid clinicians in their work.
Authors: Monica C Serra; Alexus Landry; Jorge L Juncos; Alayne D Markland; Kathryn L Burgio; Patricia S Goode; Theodore M Johnson; Camille P Vaughan Journal: Neurourol Urodyn Date: 2017-11-02 Impact factor: 2.696
Authors: Christine Lo; Siddharth Arora; Yoav Ben-Shlomo; Thomas R Barber; Michael Lawton; Johannes C Klein; Sofia Kanavou; Annette Janzen; Elisabeth Sittig; Wolfgang H Oertel; Donald G Grosset; Michele T Hu Journal: Neurology Date: 2021-02-24 Impact factor: 9.910