Literature DB >> 25446285

Inflammation and L-carnitine therapy in hemodialysis patients: a review.

Saman Khalatbari-Soltani1, Hadi Tabibi2.   

Abstract

Inflammation is a common complication in hemodialysis (HD) patients with no valid treatment strategy. In addition, carnitine deficiency occurs frequently in HD patients because of intradialytic loss of carnitine, impaired de novo carnitine renal synthesis, and reduced dietary intake. It appears that carnitine deficiency is related to inflammation in HD patients. A few clinical trials have investigated the effect of L-carnitine supplement on inflammatory markers in HD patients. All studies in this field, except one, showed that L-carnitine could significantly reduce C-reactive protein and serum amyloid A, as two systemic inflammation markers, in HD patients. Therefore, considering high prevalence of inflammation and carnitine deficiency in HD patients, L-carnitine therapy is a reasonable approach for reducing systemic inflammation and its complications in these patients.

Entities:  

Keywords:  Hemodialysis; Inflammation; L-Carnitine

Mesh：

Substances：

Year:  2014        PMID： 25446285     DOI： 10.1007/s10157-014-1061-3

Source DB:  PubMed          Journal:  Clin Exp Nephrol        ISSN： 1342-1751            Impact factor:   2.801


  54 in total

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Review 2.  Renal anaemia: recent developments, innovative approaches and future directions for improved management.

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3.  Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients.

Authors:  A Rashid Qureshi; Anders Alvestrand; José C Divino-Filho; Alberto Gutierrez; Olof Heimbürger; Bengt Lindholm; Jonas Bergström
Journal:  J Am Soc Nephrol       Date:  2002-01       Impact factor: 10.121

4.  Effects of l-carnitine supplement on serum amyloid A and vascular inflammation markers in hemodialysis patients: a randomized controlled trial.

Authors:  Hadi Tabibi; Fariba Hakeshzadeh; Mehdi Hedayati; Tahereh Malakoutian
Journal:  J Ren Nutr       Date:  2011-03-25       Impact factor: 3.655

Review 5.  C-reactive protein and other inflammatory risk markers in acute coronary syndromes.

Authors:  Gavin J Blake; Paul M Ridker
Journal:  J Am Coll Cardiol       Date:  2003-02-19       Impact factor: 24.094

6.  Oral L-carnitine: metabolite formation and hemodialysis.

Authors:  Marcus A Bain; Randall Faull; Robert W Milne; Allan M Evans
Journal:  Curr Drug Metab       Date:  2006-10       Impact factor: 3.731

7.  [Can the treatment with L-carnitine improve the inflammation in chronic hemodialysis patients?].

Authors:  G Grazi; M Meriggioli; G Donati
Journal:  G Ital Nefrol       Date:  2004 Nov-Dec

Review 8.  Erythropoiesis stimulatory agent- resistant anemia in dialysis patients: review of causes and management.

Authors:  Mehmet Kanbay; Mark A Perazella; Benan Kasapoglu; Mustafa Koroglu; Adrian Covic
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Authors:  B K Winter; G Fiskum; L L Gallo
Journal:  Br J Cancer       Date:  1995-11       Impact factor: 7.640
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  6 in total

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2.  Characterization of Exosomal SLC22A5 (OCTN2) carnitine transporter.

Authors:  Lara Console; Mariafrancesca Scalise; Annamaria Tonazzi; Nicola Giangregorio; Cesare Indiveri
Journal:  Sci Rep       Date:  2018-02-28       Impact factor: 4.379

3.  Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses.

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Journal:  J Neuroinflammation       Date:  2020-06-03       Impact factor: 8.322

4.  The efficacy of L-carnitine in improving malnutrition in patients on maintenance hemodialysis: a meta-analysis.

Authors:  Jianwei Zhou; Tubao Yang
Journal:  Biosci Rep       Date:  2020-06-26       Impact factor: 3.840

5.  L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection.

Authors:  Aouatef Bellamine; Tram N Q Pham; Jaspreet Jain; Jacob Wilson; Kazim Sahin; Frederic Dallaire; Nabil G Seidah; Shane Durkee; Katarina Radošević; Éric A Cohen
Journal:  Nutrients       Date:  2021-04-14       Impact factor: 5.717

6.  Dietary supplementary glutamine and L-carnitine enhanced the anti-cold stress of Arbor Acres broilers.

Authors:  Yang Liu; Yuying Yang; Ruizhi Yao; Yajie Hu; Peng Liu; Shuai Lian; Hongming Lv; Bin Xu; Shize Li
Journal:  Arch Anim Breed       Date:  2021-06-04
  6 in total

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