| Literature DB >> 25446167 |
Hae Jin Kee1, Soo-Na Cho2, Gwi Ran Kim2, Sin Young Choi2, Yuhee Ryu2, In Kyeom Kim3, Young Joon Hong2, Hyung Wook Park2, Youngkeun Ahn2, Jeong Gwan Cho2, Jong Chun Park2, Myung Ho Jeong4.
Abstract
Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism. Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.Entities:
Keywords: BMP2; Gallic acid; Noggin; Smad1/5/8 signaling; Vascular calcification
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Year: 2014 PMID： 25446167 DOI： 10.1016/j.vph.2014.08.005
Source DB: PubMed Journal: Vascul Pharmacol ISSN： 1537-1891 Impact factor: 5.773