Ertan Sonmez1, Kenan Ahmet Turkdogan2, Mustafa Karabacak3, Cemil Civelek4, Cahit Yilmaz5, Omer Faruk Ozer6, Umut Yücel Çavuş7. 1. Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: ertansnmz@gmail.com. 2. Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: drturkdogan@gmail.com. 3. Isparta State Hospital, Department of Emergency Medicine, Isparta, Turkey. Electronic address: drmustafa1979@hotmail.com. 4. Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: ccivelek@msn.com. 5. Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: cahityilmaz870@hotmail.com. 6. Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: omerfaruk2005@yahoo.com. 7. Dişkapi Yildirim Beyazit Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey. Electronic address: acildrumut@yahoo.com.
Abstract
OBJECTIVE: Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain. MATERIALS AND METHODS: The study included 190 patients with an initial diagnosis of acute coronary syndrome in the emergency department. Based on a definitive diagnosis, these patients were classified into 3 groups: ST-elevation myocardial infarction (STEMI), NSTE-ACS, and NCCP. RESULTS: Plasma SCUBE1 levels were significantly higher in the STEMI group when compared with those of the other groups (P < .05). They were also significantly higher in the NSTE-ACS group when compared with those of the NCCP group (P < .01). Troponin I, creatinine kinase, and creatinine kinase MB levels were significantly different in the NSTE-ACS group when compared with those of the NCCP group (P < .05). CONCLUSION: High rates of SCUBE1 were found both in the STEMI and NSTE-ACS patients. Furthermore, in the study group, SCUBE1 was an adequate marker for distinguishing NSTE-ACS from NCCP.
OBJECTIVE:Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain. MATERIALS AND METHODS: The study included 190 patients with an initial diagnosis of acute coronary syndrome in the emergency department. Based on a definitive diagnosis, these patients were classified into 3 groups: ST-elevation myocardial infarction (STEMI), NSTE-ACS, and NCCP. RESULTS: Plasma SCUBE1 levels were significantly higher in the STEMI group when compared with those of the other groups (P < .05). They were also significantly higher in the NSTE-ACS group when compared with those of the NCCP group (P < .01). Troponin I, creatinine kinase, and creatinine kinase MB levels were significantly different in the NSTE-ACS group when compared with those of the NCCP group (P < .05). CONCLUSION: High rates of SCUBE1 were found both in the STEMI and NSTE-ACS patients. Furthermore, in the study group, SCUBE1 was an adequate marker for distinguishing NSTE-ACS from NCCP.