Literature DB >> 25445738

A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses.

Emily Stone1, Heikki Haario2, J Josh Lawrence3.   

Abstract

In this paper we use a simple model of presynaptic neuromodulation of GABA signaling to decipher paired whole-cell recordings of frequency dependent cholinergic neuromodulation at CA1 parvalbumin-containing basket cell (PV BC)-pyramidal cell synapses. Variance-mean analysis is employed to normalize the data, which is then used to estimate parameters in the mathematical model. Various parameterizations and hidden parameter dependencies are investigated using Markov Chain Monte Carlo (MCMC) parameter estimation techniques. This analysis reveals that frequency dependence of cholinergic modulation requires both calcium-dependent recovery from depression and mAChR-induced inhibition of presynaptic calcium entry. A reduction in calcium entry into the presynaptic terminal in the kinetic model accounted for the frequency-dependent effects of mAChR activation.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cholinergic modulation; Hippocampal GABAergic synapses; Markov Chain Monte Carlo parameter estimation; Presynaptic depression

Mesh：

Substances：

Year:  2014        PMID： 25445738      PMCID： PMC4262556          DOI： 10.1016/j.mbs.2014.09.013

Source DB:  PubMed          Journal:  Math Biosci        ISSN： 0025-5564            Impact factor:   2.144


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