Baiqun Wu1, Xiaoming Ji1, Ruhui Han1, Lei Han1, Ting Wang1, Jingjin Yang1, Baoli Zhu2, Chunhui Ni3. 1. Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China. 2. Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, China. 3. Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China. Electronic address: chninjmu@gmail.com.
Abstract
BACKGROUND: Glucocorticoid-induced tumor necrosis factor (TNF) receptor-related protein (GITR) mainly affects the functions of effector T cells and regulatory T cells thus it may influence various diseases. Coal workers' pneumoconiosis (CWP) is a serious occupational disease worldwide. In the present study, we examined the association between the functional polymorphisms in GITR and risk of CWP in a Chinese population. METHODS: An association study analyzing three polymorphisms (rs3753348, rs2298213, and rs11466668) in GITR were performed in a case-control study including 693 patients with CWP and 690 controls. Genotyping was carried out by Taqman method. RESULTS: The GITR rs3753348 GG/GC genotypes significantly enhanced the risk of CWP (adjusted OR=1.32, 95%CI=1.02-1.71), compared with the CC genotype, particularly among subgroups of long exposure years (adjusted OR=1.47, 95%CI=1.06-2.04) and non-smokers (adjusted OR=1.45, 95%CI=1.01-2.09). Moreover, the polymorphism was significantly associated with risk for CWP cases with stage II. CONCLUSIONS: This is the first report revealing an association between the GITR rs3753348 polymorphism and CWP, and our results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.
BACKGROUND: Glucocorticoid-induced tumor necrosis factor (TNF) receptor-related protein (GITR) mainly affects the functions of effector T cells and regulatory T cells thus it may influence various diseases. Coal workers' pneumoconiosis (CWP) is a serious occupational disease worldwide. In the present study, we examined the association between the functional polymorphisms in GITR and risk of CWP in a Chinese population. METHODS: An association study analyzing three polymorphisms (rs3753348, rs2298213, and rs11466668) in GITR were performed in a case-control study including 693 patients with CWP and 690 controls. Genotyping was carried out by Taqman method. RESULTS: The GITRrs3753348 GG/GC genotypes significantly enhanced the risk of CWP (adjusted OR=1.32, 95%CI=1.02-1.71), compared with the CC genotype, particularly among subgroups of long exposure years (adjusted OR=1.47, 95%CI=1.06-2.04) and non-smokers (adjusted OR=1.45, 95%CI=1.01-2.09). Moreover, the polymorphism was significantly associated with risk for CWP cases with stage II. CONCLUSIONS: This is the first report revealing an association between the GITRrs3753348 polymorphism and CWP, and our results suggest that the GITRrs3753348 polymorphism may be involved in the development and susceptibility of CWP.
Authors: Yi Liu; Jingjin Yang; Qiuyun Wu; Ruhui Han; Weiwen Yan; Jiali Yuan; Xiaoming Ji; Yan Li; Wenxi Yao; Chunhui Ni Journal: Int J Environ Res Public Health Date: 2017-09-27 Impact factor: 3.390