AIMS: To investigate how affects electrical-conduction function following myocardial infarction (MI) in rats. MAIN METHODS: Thirty SD rats of either sex (220-250 g) were anesthetized using chlorine hydrate and were randomly divided into three groups: control group, MI group and transplantation group. The field potential (FP) morphology and activation-conduction duration were recorded with microeletrode array techniques. KEY FINDINGS: The MEA recorded clear FP morphology. Activation-conduction duration was (6.5 ± 2.12) ms in the control group, (17.5 ± 3.54) ms in the MI group, and (9.13 ± 1.31) ms in the transplantation group. SIGNIFICANCE: EHT transplantation can improve electrical-conduction and function of MI rats.
AIMS: To investigate how affects electrical-conduction function following myocardial infarction (MI) in rats. MAIN METHODS: Thirty SD rats of either sex (220-250 g) were anesthetized using chlorine hydrate and were randomly divided into three groups: control group, MI group and transplantation group. The field potential (FP) morphology and activation-conduction duration were recorded with microeletrode array techniques. KEY FINDINGS: The MEA recorded clear FP morphology. Activation-conduction duration was (6.5 ± 2.12) ms in the control group, (17.5 ± 3.54) ms in the MI group, and (9.13 ± 1.31) ms in the transplantation group. SIGNIFICANCE: EHT transplantation can improve electrical-conduction and function of MI rats.
Authors: Rosalinda Madonna; Linda W Van Laake; Hans Erik Botker; Sean M Davidson; Raffaele De Caterina; Felix B Engel; Thomas Eschenhagen; Francesco Fernandez-Aviles; Derek J Hausenloy; Jean-Sebastien Hulot; Sandrine Lecour; Jonathan Leor; Philippe Menasché; Maurizio Pesce; Cinzia Perrino; Fabrice Prunier; Sophie Van Linthout; Kirsti Ytrehus; Wolfram-Hubertus Zimmermann; Peter Ferdinandy; Joost P G Sluijter Journal: Cardiovasc Res Date: 2019-03-01 Impact factor: 10.787