Literature DB >> 25445130

[Cerebral venous thrombosis and immune thrombocytopenia in a 7-year-old girl: a fortuitous association?].

M Cotillon1, A Lebas2, T Blanc3, P Schneider4, J-P Vannier4, N Buchbinder4.   

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by autoantibody-mediated peripheral platelet destruction. It is rarely accompanied by thrombosis. Here, we describe a wide cerebral venous thrombosis that occurred at the onset of a primary ITP in a 7-year-old girl. ITP was confirmed by the presence of anti-platelet antibodies. Whether ITP is a risk factor for venous thrombosis is a matter of debate. The platelet microparticles released during the platelet destruction and the interaction between the autoantibodies and the platelet glycoproteins may contribute to platelet activation. Increased risk of thromboembolic events should be considered in all patients with ITP, including children.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

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Year:  2014        PMID: 25445130     DOI: 10.1016/j.arcped.2014.09.014

Source DB:  PubMed          Journal:  Arch Pediatr        ISSN: 0929-693X            Impact factor:   1.180


  1 in total

1.  Cerebral Venous Thrombosis after Intravenous Immunoglobulin Therapy in Immune Thrombocytopenic Purpura.

Authors:  Joe James; P V Shiji; Chandni Radhakrishnan
Journal:  Indian J Crit Care Med       Date:  2017-12
  1 in total

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