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Literature DB >> 25444993

Repair mechanisms help glioblastoma resist treatment.

Ryan J Atkins¹, Wayne Ng², Stanley S Stylli², Christopher M Hovens³, Andrew H Kaye².

Abstract

Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.

Entities: Chemical Disease Species

Keywords: Base excision repair; Glioma resistance; MGMT; PARP; Temozolomide chemotherapy

Mesh：

Substances：

Year: 2014 PMID： 25444993 DOI： 10.1016/j.jocn.2014.09.003

Source DB: PubMed Journal: J Clin Neurosci ISSN： 0967-5868 Impact factor: 1.961

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Cited

24 in total

Review 1. Nanomedicine associated with photodynamic therapy for glioblastoma treatment.

Authors: Leonardo B de Paula; Fernando L Primo; Antonio C Tedesco
Journal: Biophys Rev Date: 2017-08-19

2. MicroRNA-590-3p enhances the radioresistance in glioblastoma cells by targeting LRIG1.

Authors: Long Chen; Wenhua Wang; Shengqiang Zhu; Xuegang Jin; Jian Wang; Jianfang Zhu; Youxin Zhou
Journal: Exp Ther Med Date: 2017-06-28 Impact factor: 2.447

3. LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.

Authors: Ji-An Yang; Bao-Hui Liu; Ling-Min Shao; Zhen-Tao Guo; Qian Yang; Li-Quan Wu; Bao-Wei Ji; Xiao-Nan Zhu; Shen-Qi Zhang; Cheng-Jun Li; Qian-Xue Chen
Journal: Int J Clin Exp Pathol Date: 2015-04-01

4. Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.

Authors: Yajing Liu; Wenbin Ji; Andrea Shergalis; Jiaqi Xu; Amy M Delaney; Andrew Calcaterra; Anupama Pal; Mats Ljungman; Nouri Neamati; Alnawaz Rehemtulla
Journal: Cancer Res Date: 2019-04-17 Impact factor: 12.701

5. RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.

Authors: Ann C Mladek; Huihuang Yan; Shulan Tian; Paul A Decker; Danielle M Burgenske; Katrina Bakken; Zeng Hu; Lihong He; Margaret A Connors; Brett L Carlson; Jonathan Wilson; Archana Bommi-Reddy; Andy Conery; Jeanette E Eckel-Passow; Jann N Sarkaria; Gaspar J Kitange
Journal: Neuro Oncol Date: 2022-08-01 Impact factor: 13.029

Review 10. Radioresistance of Brain Tumors.

Authors: Kevin Kelley; Jonathan Knisely; Marc Symons; Rosamaria Ruggieri
Journal: Cancers (Basel) Date: 2016-03-30 Impact factor: 6.639

Repair mechanisms help glioblastoma resist treatment.

Review 1. Nanomedicine associated with photodynamic therapy for glioblastoma treatment.

2. MicroRNA-590-3p enhances the radioresistance in glioblastoma cells by targeting LRIG1.

3. LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.

4. Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.

5. RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.

6. The expression of miRNA-221 and miRNA-222 in gliomas patients and their prognosis.

7. BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.

Review 8. Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review).

9. Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review.

Review 10. Radioresistance of Brain Tumors.