Henryk F Urbanski1. 1. Division of Neuroscience and Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA. Electronic address: urbanski@ohsu.edu.
Abstract
BACKGROUND: In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II). STUDY DESIGN: The effect of estradiol on GnRH gene expression was examined. RESULTS: Estradiol inhibited GnRH-I neurons but stimulated GnRH-II neurons, suggesting that GnRH-II neurons play the dominant role in mediating estradiol-positive feedback and triggering the midcycle preovulatory LH surge. CONCLUSIONS: Selective silencing of GnRH-II neurons in women could serve as a novel contraceptive, by blocking ovulation while leaving the rest of the reproductive axis relatively unperturbed.
BACKGROUND: In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II). STUDY DESIGN: The effect of estradiol on GnRH gene expression was examined. RESULTS:Estradiol inhibited GnRH-I neurons but stimulated GnRH-II neurons, suggesting that GnRH-II neurons play the dominant role in mediating estradiol-positive feedback and triggering the midcycle preovulatory LH surge. CONCLUSIONS: Selective silencing of GnRH-II neurons in women could serve as a novel contraceptive, by blocking ovulation while leaving the rest of the reproductive axis relatively unperturbed.
Authors: D W Lescheid; E Terasawa; L A Abler; H F Urbanski; C M Warby; R P Millar; N M Sherwood Journal: Endocrinology Date: 1997-12 Impact factor: 4.736
Authors: V S Latimer; S M Rodrigues; V T Garyfallou; S G Kohama; R B White; R D Fernald; H F Urbanski Journal: Brain Res Mol Brain Res Date: 2000-02-22
Authors: Amy T Desaulniers; Rebecca A Cederberg; Clay A Lents; Brett R White Journal: Front Endocrinol (Lausanne) Date: 2017-12-11 Impact factor: 5.555