Ioana Mozos1. 1. "Victor Babes" University of Medicine and Pharmacy Department of Functional Sciences, Timisoara, Romania. Electronic address: ioanamozos@yahoo.de.
Abstract
AIM: To assess the relationship between repolarization variables and arterial function. METHODS: A total of 54 participants, aged 33±10years, underwent arteriography and standard 12-lead electrocardiography (ECG). Arteriography was performed using a noninvasive automated oscillometric method, assessing: brachial (Aix Brach) and aortic augmentation index (Aix Ao), pulse wave velocity (PWV), arterial age (AA), diastolic reflection area (DRA) and diastolic area index (DAI). Standard 12-lead ECG enabled measurement of QT and Tpeak-Tend (TpTe) intervals and TpTe/QT ratios. RESULTS: QT interval was prolonged in patients with elevated blood pressure or body mass index. Significant associations were found between electrocardiographic repolarization parameters, such as QT intervals, TpTe and TpTe/QT and arteriography variables, such as Aix Brach, Aix Ao, PWV and AA. CONCLUSION: Prolonged QTc and Tpe are associated with endothelial dysfunction, arterial stiffness, impaired coronary perfusion and accelerated arterial aging.
AIM: To assess the relationship between repolarization variables and arterial function. METHODS: A total of 54 participants, aged 33±10years, underwent arteriography and standard 12-lead electrocardiography (ECG). Arteriography was performed using a noninvasive automated oscillometric method, assessing: brachial (Aix Brach) and aortic augmentation index (Aix Ao), pulse wave velocity (PWV), arterial age (AA), diastolic reflection area (DRA) and diastolic area index (DAI). Standard 12-lead ECG enabled measurement of QT and Tpeak-Tend (TpTe) intervals and TpTe/QT ratios. RESULTS: QT interval was prolonged in patients with elevated blood pressure or body mass index. Significant associations were found between electrocardiographic repolarization parameters, such as QT intervals, TpTe and TpTe/QT and arteriography variables, such as Aix Brach, Aix Ao, PWV and AA. CONCLUSION: Prolonged QTc and Tpe are associated with endothelial dysfunction, arterial stiffness, impaired coronary perfusion and accelerated arterial aging.
Authors: Gary Tse; George Bazoukis; Leonardo Roever; Tong Liu; William K K Wu; Martin C S Wong; Adrian Baranchuk; Panagiotis Korantzopoulos; Dimitrios Asvestas; Konstantinos P Letsas Journal: Curr Atheroscler Rep Date: 2018-09-17 Impact factor: 5.113