Literature DB >> 25444520

Corneal lymphangiogenesis in herpetic stromal keratitis.

Paul J Park1, Michael Chang1, Nitin Garg1, Jimmy Zhu2, Jin-Hong Chang2, Deepak Shukla3.   

Abstract

Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immune- and inflammation-mediated damage to the deep layers of the cornea. Current research demonstrates the potential of anti-lymphangiogenic therapy to decrease and prevent herpes-induced lymphangiogenesis.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cornea; herpes simplex virus-1; lymphangiogenesis; neovascularization; vascular endothelial growth factor (VEGF)

Mesh：

Year:  2014        PMID： 25444520      PMCID： PMC4262646          DOI： 10.1016/j.survophthal.2014.06.001

Source DB:  PubMed          Journal:  Surv Ophthalmol        ISSN： 0039-6257            Impact factor:   6.048


  154 in total

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