Literature DB >> 2544414

Interleukin-6 stimulates anterior pituitary hormone release in vitro.

B L Spangelo1, A M Judd, P C Isakson, R M MacLeod.   

Abstract

Interleukin-6 (IL-6), a cytokine produced by inflammatory reactions, was found to stimulate PRL, GH and LH release from anterior pituitary cells at concentrations similar to those which affected lymphocyte mitogenesis. Perifused pituitary cells responded to IL-6 with prompt increases in hormone release that declined rapidly following cessation of exposure. Dopamine (DA) attenuated IL6-induced PRL release. In addition, IL-6 potentiated both GHRF- and TRH-induced hormone release without an affect on intracellular cAMP. These data demonstrate a new biological activity for IL-6 and provide evidence for immune system regulation of anterior pituitary hormone release.

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Year:  1989        PMID： 2544414     DOI： 10.1210/endo-125-1-575

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  31 in total

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Authors:  A R Rezai; A Rezai; O Martínez-Maza; M Vander-Meyden; M H Weiss
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10.  Anterior pituitary hormone control by interleukin 2.

Authors:  S Karanth; S M McCann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205
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