Hiroyasu Iso1, Hironori Imano2, Kazumasa Yamagishi3, Tetsuya Ohira2, Renzhe Cui4, Hiroyuki Noda4, Shinichi Sato5, Masahiko Kiyama6, Takeo Okada6, Shinichi Hitsumoto7, Takeshi Tanigawa8, Akihiko Kitamura6. 1. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan. Electronic address: iso@pbhel.med.osaka-u.ac.jp. 2. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan. 3. Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. 4. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan. 5. Chiba Prefectural Institute of Public Health, Nitona Government Office Building, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8715, Japan. 6. Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan. 7. Total Medical Support Center, Ehime University Hospital, 454 Shitsukawa, Toon, 791-0295, Japan. 8. Department of Environmental Health and Social Medicine, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791-0295, Japan.
Abstract
BACKGROUND: Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. METHODS: We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants. RESULTS: During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. CONCLUSION: Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.
BACKGROUND: Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. METHODS: We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants. RESULTS: During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. CONCLUSION: Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.
Authors: Peter Sabaka; Peter Kruzliak; David Balaz; Andrea Komornikova; Denisa Celovska; Giovanni Cammarota; Katarina Kusendova; Matej Bendzala; Luis Rodrigo; Andrej Dukat; Taeg Kyu Kwon; Magdalena Chottova Dvorakova; Ludovit Gaspar Journal: Lipids Health Dis Date: 2015-11-25 Impact factor: 3.876