Literature DB >> 25443749

Human-chimpanzee alignment: ortholog exponentials and paralog power laws.

Kun Gao1, Jonathan Miller2.   

Abstract

Genomic subsequences conserved between closely related species such as human and chimpanzee exhibit an exponential length distribution, in contrast to the algebraic length distribution observed for sequences shared between distantly related genomes. We find that the former exponential can be further decomposed into an exponential component primarily composed of orthologous sequences, and a truncated algebraic component primarily composed of paralogous sequences.
Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Evolution; Exponential and Power-law; Genomic alignment; Length distribution; Orthology and paralogy

Mesh:

Year:  2014        PMID: 25443749     DOI: 10.1016/j.compbiolchem.2014.08.010

Source DB:  PubMed          Journal:  Comput Biol Chem        ISSN: 1476-9271            Impact factor:   2.877


  5 in total

1.  Comparing the Statistical Fate of Paralogous and Orthologous Sequences.

Authors:  Florian Massip; Michael Sheinman; Sophie Schbath; Peter F Arndt
Journal:  Genetics       Date:  2016-07-29       Impact factor: 4.562

Review 2.  Mappability and read length.

Authors:  Wentian Li; Jan Freudenberg
Journal:  Front Genet       Date:  2014-11-10       Impact factor: 4.599

3.  How evolution of genomes is reflected in exact DNA sequence match statistics.

Authors:  Florian Massip; Michael Sheinman; Sophie Schbath; Peter F Arndt
Journal:  Mol Biol Evol       Date:  2014-11-13       Impact factor: 16.240

4.  Size distribution of function-based human gene sets and the split-merge model.

Authors:  Wentian Li; Oscar Fontanelli; Pedro Miramontes
Journal:  R Soc Open Sci       Date:  2016-08-03       Impact factor: 2.963

5.  Primary orthologs from local sequence context.

Authors:  Kun Gao; Jonathan Miller
Journal:  BMC Bioinformatics       Date:  2020-02-06       Impact factor: 3.169

  5 in total

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