Rose M Collard1, Matheus Arts2, Hannie C Comijs3, Paul Naarding4, Peter F M Verhaak5, Margot W de Waal6, Richard C Oude Voshaar7. 1. Department of Psychiatry, University Medical Centre St. Radboud, Nijmegen, The Netherlands; Pro Persona, Nijmegen Mental Health Centre, The Netherlands. Electronic address: rose.collard@radboudumc.nl. 2. University Center for Psychiatry and Interdisciplinary Center for Psychopathology of Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 3. Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; GGZinGeest, Amsterdam, The Netherlands. 4. Department of Psychiatry, University Medical Centre St. Radboud, Nijmegen, The Netherlands; GGNet, Department of Old-age Psychiatry, Apeldoorn/Zutphen, The Netherlands. 5. Department General Practice, University Medical Center Groningen, University of Groningen, The Netherlands; NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands. 6. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. 7. Department of Psychiatry, University Medical Centre St. Radboud, Nijmegen, The Netherlands; University Center for Psychiatry and Interdisciplinary Center for Psychopathology of Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
BACKGROUND: Depression and physical frailty in older persons are both associated with somatic diseases, but are hardly examined in concert. OBJECTIVES: To examine whether depression and physical frailty act independently and/or synergistically in their association with somatic diseases. DESIGN: Baseline data of an ongoing observational cohort study including depressed cases and non-depressed comparison subjects. SETTINGS: Netherlands Study of Depression in Older persons (NESDO). PARTICIPANTS: 378 depressed older persons confirmed by the Composite International Diagnostic Interview (CIDI), version 2.1, and 132 non-depressed comparison subjects. METHODS: Multiple linear regression analyses adjusted for socio-demographic and life-style characteristics were conducted with the number of somatic diseases as the dependent variable and depression and physical frailty as independent variables. Physical frailty was defined as ≥3 of the following characteristics, slowness, low physical activity, weight loss, exhaustion, and weakness. RESULTS: Depression and physical frailty did not interact in explaining variance in the number of somatic diseases (p=.57). Physical frailty, however, partly mediated the association between depression and somatic diseases, as the strength of this association decreased by over 10% when frailty was added to the model (B=0.47, p=.003, versus B=0.41, p=.01). The mediation effect was primarily driven by the frailty criterion exhaustion. Of the remaining frailty components, only slowness was associated with the number of somatic diseases; but this association was fully independent of depression. CONCLUSIONS: Our results suggest that depression and physical frailty have common pathways towards somatic diseases, as well as unique pathways. As no high-risk group was identified (no significant interaction), mental health nurses should regularly monitor for physical frailty within their caseload of depressed patients.
BACKGROUND:Depression and physical frailty in older persons are both associated with somatic diseases, but are hardly examined in concert. OBJECTIVES: To examine whether depression and physical frailty act independently and/or synergistically in their association with somatic diseases. DESIGN: Baseline data of an ongoing observational cohort study including depressed cases and non-depressed comparison subjects. SETTINGS: Netherlands Study of Depression in Older persons (NESDO). PARTICIPANTS: 378 depressed older persons confirmed by the Composite International Diagnostic Interview (CIDI), version 2.1, and 132 non-depressed comparison subjects. METHODS: Multiple linear regression analyses adjusted for socio-demographic and life-style characteristics were conducted with the number of somatic diseases as the dependent variable and depression and physical frailty as independent variables. Physical frailty was defined as ≥3 of the following characteristics, slowness, low physical activity, weight loss, exhaustion, and weakness. RESULTS:Depression and physical frailty did not interact in explaining variance in the number of somatic diseases (p=.57). Physical frailty, however, partly mediated the association between depression and somatic diseases, as the strength of this association decreased by over 10% when frailty was added to the model (B=0.47, p=.003, versus B=0.41, p=.01). The mediation effect was primarily driven by the frailty criterion exhaustion. Of the remaining frailty components, only slowness was associated with the number of somatic diseases; but this association was fully independent of depression. CONCLUSIONS: Our results suggest that depression and physical frailty have common pathways towards somatic diseases, as well as unique pathways. As no high-risk group was identified (no significant interaction), mental health nurses should regularly monitor for physical frailty within their caseload of depressed patients.
Authors: Rose M Collard; Hannie C Comijs; Paul Naarding; Brenda W Penninx; Yuri Milaneschi; Luigi Ferrucci; Richard C Oude Voshaar Journal: J Am Med Dir Assoc Date: 2015-02-27 Impact factor: 4.669
Authors: David Bickford; Ruth T Morin; Cara Woodworth; Elizabeth Verduzco; Maryam Khan; Emily Burns; J Craig Nelson; R Scott Mackin Journal: Aging Ment Health Date: 2019-12-06 Impact factor: 3.658
Authors: Ivan Aprahamian; Ronei Luciano Mamoni; Nilva Karla Cervigne; Taize Machado Augusto; Carla Vasconcelos Romanini; Marina Petrella; Daniele Lima da Costa; Natalia Almeida Lima; Marcus K Borges; Richard C Oude Voshaar Journal: BMC Psychiatry Date: 2020-12-01 Impact factor: 3.630