Literature DB >> 25442661

Biological knee reconstruction for combined malalignment, meniscal deficiency, and articular cartilage disease.

Joshua D Harris1, Kristen Hussey2, Hillary Wilson2, Kyle Pilz2, Anil K Gupta2, Andreas Gomoll3, Brian J Cole4.   

Abstract

PURPOSE: The aim of this study was to analyze patient-reported outcomes in those undergoing the triad of simultaneous osteotomy, meniscal transplantation, and articular cartilage repair.
METHODS: Patients undergoing simultaneous meniscal transplantation, distal femoral or proximal tibial osteotomy, and articular cartilage surgery by a single surgeon (B.J.C.) were analyzed. Meniscal transplantation was performed using bone-in-slot techniques. Distal femoral and high tibial osteotomies were performed for valgus and varus malalignment, respectively. Microfracture, autologous chondrocyte implantation, and osteochondral autograft or allograft were performed for articular cartilage disease. Validated patient-reported and surgeon-measured outcomes were collected. Preoperative and postoperative outcomes and medial versus lateral disease were compared using Student t tests.
RESULTS: Eighteen participants (mean age, 34 ± 7.8 years; symptomatic patients, 7.4 ± 5.6 years; 2.4 ± 1.0 surgical procedures before study enrollment; mean follow-up, 6.5 ± 3.2 years) were analyzed. Two thirds of participants had medial compartment pathologic conditions and one third had lateral compartment pathologic processes. At final follow-up, there were statistically significant clinically meaningful improvements in International Knee Documentation Committee (IKDC) subjective classification, Lysholm score, and 4 Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores. Postoperative 12-item short form (SF-12) physical and mental component scores were not significantly different from preoperative scores. The Kellgren-Lawrence classification grade was 1.5 ± 1.1 at 2.5 ± 3.0 years after surgery. There was a significantly higher preoperative SF-12 physical composite score (PCS) in participants with lateral compartment pathologic conditions (v medial compartment conditions) (P = .011). Although there were 13 reoperations in 10 patients (55.5% reoperation rate), only one patient was converted to knee arthroplasty (5.6%) and one to revision cartilage surgery and meniscal transplantation (5.6% revision rate). The most common complication was arthrofibrosis (16.7%).
CONCLUSIONS: Statistically significant and clinically meaningful improvements in validated patient-reported clinical outcome scores at long-term follow-up were observed in 18 participants undergoing combined meniscal transplantation, osteotomy, and articular cartilage surgery. Although there was a low rate of cartilage or meniscal revision (or both) and total knee arthroplasty, there was a high rate of reoperation. There was no significant difference in outcomes between participants with medial versus lateral pathologic conditions. LEVEL OF EVIDENCE: Level IV, therapeutic case series.
Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

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Year:  2014        PMID: 25442661     DOI: 10.1016/j.arthro.2014.08.012

Source DB:  PubMed          Journal:  Arthroscopy        ISSN: 0749-8063            Impact factor:   4.772


  15 in total

1.  Correlation of SF-36 and SF-12 Component Scores in Patients With Diabetic Foot Disease.

Authors:  Dane K Wukich; Tresa L Sambenedetto; Natalie M Mota; Natalie C Suder; Bedda L Rosario
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Review 2.  Chondral and osteochondral operative treatment in early osteoarthritis.

Authors:  Peter Angele; Philipp Niemeyer; Matthias Steinwachs; Giuseppe Filardo; Andreas H Gomoll; Elizaveta Kon; Johannes Zellner; Henning Madry
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-02-27       Impact factor: 4.342

3.  Defining outcome after meniscal allograft transplantation: Is buying time a valid measure of success?

Authors:  Tim Spalding; Alan Getgood
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-05       Impact factor: 4.342

4.  Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury.

Authors:  Deva D Chan; Jun Li; Wei Luo; Dan N Predescu; Brian J Cole; Anna Plaas
Journal:  J Orthop Res       Date:  2017-07-21       Impact factor: 3.494

5.  Biologic Joint Restoration: A Translational Research Success Story.

Authors:  James L Cook; James P Stannard; Aaron M Stoker; Kylee Rucinski; Brett D Crist; Cristi R Cook; Cory Crecelius; Matthew J Smith; Renee Stucky
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6.  Recent advances and future directions in the management of knee osteoarthritis: Can biological joint reconstruction replace joint arthroplasty and when?

Authors:  Nikolaos K Paschos
Journal:  World J Orthop       Date:  2015-10-18

7.  Meniscal Allograft Transplantation With Concomitant Osteochondral Allograft Transplantation.

Authors:  Eric J Cotter; Rachel M Frank; Brian R Waterman; Kevin C Wang; Michael L Redondo; Brian J Cole
Journal:  Arthrosc Tech       Date:  2017-10-12

Review 8.  Large Osteochondral Allografts of the Knee: Surgical Technique and Indications.

Authors:  Gabriele Pisanu; Umberto Cottino; Federica Rosso; Davide Blonna; Antonio Giulio Marmotti; Corrado Bertolo; Roberto Rossi; Davide E Bonasia
Journal:  Joints       Date:  2018-03-13

9.  Multiple Osteochondral Allograft Transplantation with Concomitant Tibial Tubercle Osteotomy for Multifocal Chondral Disease of the Knee.

Authors:  Eric J Cotter; Brian R Waterman; Mick P Kelly; Kevin C Wang; Rachel M Frank; Brian J Cole
Journal:  Arthrosc Tech       Date:  2017-08-21

10.  High Tibial Osteotomy for Varus Deformity of the Knee.

Authors:  Ryan Murray; Philipp W Winkler; Humza S Shaikh; Volker Musahl
Journal:  J Am Acad Orthop Surg Glob Res Rev       Date:  2021-07-09
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