| Literature DB >> 25442320 |
Yu-jie Huang1, Hui Lu1, Xue-li Yu1, Wei-bing Song1, Shu-wei Zhang1, Lin-yin Fen1, Li-jiang Xuan2.
Abstract
A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 52.78 ± 8.61, 0.69 ± 0.23 and 5.18 ± 1.33, respectively, while indomethacin, the positive control, showed an IC50 value of 1.25 ± 0.52 μM.Entities:
Keywords: Anti-inflammatory; Gentianella azurea (Gentianaceae); Nitric oxide; Secoiridoid glucosides
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Year: 2014 PMID： 25442320 DOI： 10.1016/j.bmcl.2014.09.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823